Leptin deficiency in maltreated children.
Leptin deficiency in maltreated children.
复制标题
虐待儿童的瘦素缺乏。
DOI：
10.1038/tp.2014.79
复制
发表时间：
2014-09-23
影响因子：
6.8
通讯作者：
Arseneault L
中科院分区：
文献类型：
--
作者：
Danese A;Dove R;Belsky DW;Henchy J;Williams B;Ambler A;Arseneault L
与对早期生活压力下的非人类灵长类动物进行的实验研究结果一致，遭受虐待的儿童患肥胖症和全身性炎症等有害身体健康状况的风险很高。由于瘦素是参与能量平衡和免疫调节的关键分子，我们研究了受虐待儿童瘦素生理异常。我们测量了170名参加环境风险纵向双胞胎研究的12岁儿童的瘦素、体重指数和c反应蛋白，我们对这些儿童前瞻性地收集了虐待暴露的信息。我们发现，与性别、合子性和社会经济地位相匹配的一组未受虐待的儿童相比，受虐待儿童瘦素水平的升高与生理刺激、肥胖和炎症水平的增加有关。这些发现也独立于关键的潜在人为因素和混杂因素，如采集样本的时间、食物不安全史、青春期成熟和抑郁症状。此外，使用出生体重作为瘦素的替代测量，我们发现生理异常可能不会在出生时出现在继续遭受虐待的儿童中，而只是在童年时期遭受虐待后出现。瘦素缺乏可能导致受虐待儿童身体健康问题的发生、持续和发展。
Consistent with findings from experimental research in nonhuman primates exposed to early-life stress, children exposed to maltreatment are at high risk of detrimental physical health conditions, such as obesity and systemic inflammation. Because leptin is a key molecule involved in the regulation of both energy balance and immunity, we investigated abnormalities in leptin physiology among maltreated children. We measured leptin, body mass index and C-reactive protein in 170 12-year-old children members of the Environmental-Risk Longitudinal Twin Study, for whom we had prospectively-collected information on maltreatment exposure. We found that maltreated children exhibited blunted elevation in leptin levels in relation to increasing levels of physiological stimuli, adiposity and inflammation, compared with a group of non-maltreated children matched for gender, zygosity and socioeconomic status. These findings were also independent of key potential artifacts and confounders, such as time of day at sample collection, history of food insecurity, pubertal maturation and depressive symptoms. Furthermore, using birth weight as a proxy measure for leptin, we found that physiological abnormalities were presumably not present at birth in children who went on to be maltreated but only emerged over the course of childhood, after maltreatment exposure. Leptin deficiency may contribute to onset, persistence and progression of physical health problems in maltreated children.
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影响因子：
7.6
作者：
Jaffee, Sara R.;Bowes, Lucy;Arseneault, Louise
通讯作者：
Arseneault, Louise
影响因子：
2.9
作者：
Adam, Tanja C.;Epel, Elissa S.
通讯作者：
Epel, Elissa S.
影响因子：
17.7
作者：
Nanni, Valentina;Uher, Rudolf;Danese, Andrea
通讯作者：
Danese, Andrea
DOI：
10.1073/pnas.1218253109
发表时间：
2012-12-11
影响因子：
11.1
作者：
Cole, Steven W.;Conti, Gabriella;Suomi, Stephen J.
通讯作者：
Suomi, Stephen J.
影响因子：
7.6
作者：
Moffitt, TE
通讯作者：
Moffitt, TE