Blood-Flow Velocity in Glaucoma Patients Measured with the Retinal Function Imager
Blood-Flow Velocity in Glaucoma Patients Measured with the Retinal Function Imager
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DOI：
10.3109/02713683.2015.1080278
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发表时间：
2016-07-01
影响因子：
2
通讯作者：
Gaton, Dan
中科院分区：
文献类型：
--
作者：
Burgansky-Eliash, Zvia;Bartov, Elisha;Gaton, Dan
目的：青光眼患者视网膜、视神经和脉络膜的循环异常已被各种技术检测到。然而，对于血流在青光眼中的作用还没有明确的认识。材料与方法：应用视网膜功能成像仪（RFI）对46例原发性开角型青光眼（POAG）患者59只眼、31例健康人51只眼和23例视野正常的青光眼性视神经病变（GON）患者28只眼的视网膜血流速度进行比较。青光眼组2例患者的3只眼和GON组1例患者的2只眼在诊断时血压正常。83%的青光眼患者和73%的GON组患者接受了抗青光眼药物治疗。所有患者均行RFI扫描。结果：GON组平均静脉流速（3.8 mm/s）明显快于青光眼组（3.3 mm/s，p = 0.03）和健康组（3.0 mm/s，p = 0.005）。GON组的动脉流速与其他研究组无差异（4.7 mm/s）。POAG眼的动脉和静脉流速与健康眼无差异（动脉：4.3 vs 4.2 mm/s，p = 0.7;静脉：3.3 vs 3.0 mm/s，p = 0.3）。一个亚组的13例青光眼患者谁有周边青光眼的1只眼睛和正常的视野（VF）在对眼显示出较低的速度在青光眼eyes.Conclusions的趋势：视网膜血流速度的变化只检测到在前周边状态，但不是在周边青光眼。这些发现可能代表视网膜血管系统的早期失调。
Purpose: Circulatory abnormalities in the retina, optic nerve and choroid have been detected by various technologies in glaucoma patients. However, there is no clear understanding of the role of blood flow in glaucoma. The purpose of this study was to compare retinal blood-flow velocities using the retinal function imager (RFI) between glaucoma and healthy subjects.Materials and Methods: Fifty-nine eyes of 46 patients with primary open-angle glaucoma (POAG), 51 eyes of 31 healthy individuals and 28 eyes of 23 patients with glaucomatous optic neuropathy (GON) but normal perimetry were recruited for this study. Three eyes of 2 patients in the glaucoma group and 2 eyes of 1 patient in the GON group had normal pressure at the time of diagnosis. Eighty-three percent of the glaucoma patients and 73% of the patients in the GON group were treated with anti-glaucoma medications. All patients were scanned by the RFI. Differences among groups were assessed by mixed linear models.Results: The average venous velocity in the GON group (3.8 mm/s) was significantly faster than in the glaucoma (3.3 mm/s, p = 0.03) and healthy (3.0 mm/s, p = 0.005) groups. The arterial velocity in the GON group was not different from any of the other study groups (4.7 mm/s). The arterial and venous velocity in the POAG eyes was not different than in the healthy eyes (arterial: 4.3 versus 4.2 mm/s, p = 0.7; venous: 3.3 versus 3.0 mm/s, p = 0.3). A subgroup of 13 glaucoma patients who had perimetric glaucoma in 1 eye and normal visual field (VF) in the fellow eye showed a trend of lower velocity in the glaucoma eyes.Conclusions: Changes in retinal blood-flow velocity were detected only in the pre-perimetric state, but not in perimetric glaucoma. These findings might represent early dysregulation in the retinal vasculature.