Relationship of interleukin-6 and tumor necrosis factor-α with muscle mass and muscle strength in elderly men and women:: The health ABC study
Relationship of interleukin-6 and tumor necrosis factor-α with muscle mass and muscle strength in elderly men and women:: The health ABC study
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DOI：
10.1093/gerona/57.5.m326
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发表时间：
2002-05-01
影响因子：
5.1
通讯作者：
Harris, TB
中科院分区：
文献类型：
--
作者：
Visser, M;Pahor, M;Harris, TB
背景。肌肉质量和肌肉力量的下降是正常衰老的特征。由于临床和动物研究表明较高的细胞因子水平与较低的肌肉质量之间存在关系，因此本研究的目的是调查炎症标志物是否与功能良好的老年人的肌肉质量和力量相关。方法。我们使用了健康、衰老和身体成分 (Health ABC) 研究的基线数据 (1997-1998)，该研究对 3075 名 70-79 岁的黑人和白人男性和女性进行了研究。大腿中部肌肉横截面积（计算机断层扫描）、四肢肌肉质量（双能 X 射线吸收法）。等速伸膝肌力 (KinCom)。测量了等长 inip 强度。通过酶联免疫吸附测定 (ELISA) 评估血浆白细胞介素 6 (IL-6) 和肿瘤坏死因子-α (TNF-α) 水平。结果。较高的细胞因子水平通常与较低的肌肉质量和较低的肌肉力量相关。在不同性别和种族群体中，IL-6 和握力之间存在最一致的关系：IL-6 每增加一个 SD，在调整年龄、诊所地点后，握力就会降低 1.1 至 2.4 公斤 (p < .05)。健康状况、药物、体力活动。吸烟。高度。和身体脂肪。所有细胞因子水平升高的总体测量都是通过结合 IL-6 和 TNF-α 的水平来创建的。除白人男性外，IL-6水平较高（> 1.80 pg/ml）和TNF-α水平较高（> 3.20 pg/ml）的老年人的肌肉面积较小，阑尾质量也较小。较低的膝伸肌力量。与两种细胞因子水平较低的人相比，握力较低。结论。对于功能良好的老年男性和女性来说，较高的血浆 IL-6 和 TNF-α 浓度与较低的肌肉质量和较低的肌肉强度有关。细胞因子水平较高。正如在健康老年人中经常观察到的那样。可能会导致伴随衰老的肌肉质量和力量的损失。
Background. A decline in muscle mass and muscle strength characterizes normal aging. As clinical and animal studies show it relationship between higher cytokine levels and low muscle mass, the aim of this study was to investigate whether markers, of inflammation are associated with muscle mass and strength in well-functioning elderly persons.Methods. We Used baseline data (1997-1998) of the Health, Aging, and Body Composition (Health ABC) Study on 3075 black and white men and women aged 70-79 years. Midthigh muscle cross-sectional area (computed tomography), appendicular muscle mass (dual-energy x-ray ab absorptiometry). isokinetic knee extensor strength (KinCom). and isometric inip strength were measured. plasma levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were assessed by enzyme-linked immunosorbent assay (ELISA).Results. Higher cytokine levels were generally associated with lower muscle mass and lower muscle strength. The most consistent relationship across the gender and race groups was observed for IL-6 and grip strength: per SD increase in IL-6, grip strength was 1.1 to 2.4 kg lower (p < .05) after adjustment for age, clinic Site. health status, medications, physical activity. smoking. height. and body fat. Ail overall measure of elevated cytokine level was created by combining the levels of IL-6 and TNF-alpha. With the exception of white men, elderly persons having high levels of IL-6 (> 1.80 pg/ml) as well as high levels of TNF-alpha (> 3.20 pg/ml) had a smaller muscle area, less appendicular mass. a lower knee extensor strength. and a lower grip strength compared to those with low levels of both cytokines.Conclusions. Higher plasma concentrations of IL-6 and TNF-alpha are associated with lower muscle mass and lower muscle strength in well-functioning older men and women. Higher cytokine levels. as often observed in healthy older persons. may contribute to the loss Of muscle mass and strength that accompanies aging.