An outbreak of rotavirus infection among adults in an institution for rehabilitation: long-term residence in a closed community as a risk factor for rotavirus illness
An outbreak of rotavirus infection among adults in an institution for rehabilitation: long-term residence in a closed community as a risk factor for rotavirus illness
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DOI：
10.1080/00365540500532134
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发表时间：
2006-07-01
影响因子：
--
通讯作者：
Kobayashi, Nobumichi
中科院分区：
文献类型：
--
作者：
Iijima, Yoshio;Iwamoto, Tomotada;Kobayashi, Nobumichi
日本科比一家隔离康复机构爆发A组轮状病毒感染，导致残疾成年人出现胃肠炎。在95名居民中，16人被诊断患有轮状病毒病。病原体是属于VP 7血清型G2、VP 4基因型P[4]和NSP 4基因型A的典型人A组轮状病毒的单一毒株。轮状病毒病患者的平均住院时间（22.19 +/- 11.8年）显著长于非轮状病毒病患者（13.59 +/- 10.6年; P = 0.01）。年龄、性别、残疾程度、住院病房所在地与疾病无显著相关性。这些观察结果表明，长期居住在一个封闭的社区，这可能与缺乏免疫刺激，轮状病毒疾病的危险因素。
An outbreak of group A rotavirus infection resulted in gastroenteritis among disabled adults in an isolated rehabilitation institution in Kobe, Japan. Of the 95 residents, 16 were diagnosed with rotavirus illness. The causative agent was a single strain of typical human group A rotavirus belonging to VP7 serotype G2, VP4 genotype P[4], and NSP4 genotype A. Mean duration of stay was significantly longer for residents with rotavirus illness (22.19 +/- 11.8 years) than for residents without the disease (13.59 +/- 10.6 years; P = 0.01). Age, sex, disability and location of resident rooms displayed no significant relationships with illness. These observations suggest that long-term residence in a closed community, which might be related to absence of immuno-stimulation, represents a risk factor for rotavirus illness.