Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT
Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE2 production in a human keratinocyte cell line HaCaT
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DOI：
10.1016/j.intimp.2010.07.010
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发表时间：
2010-10-01
影响因子：
5.6
通讯作者：
Hu, Jinhong
中科院分区：
文献类型：
--
作者：
Huang, Jin;Qiu, Lei;Hu, Jinhong
人参皂苷Rb1 （GRb1）和芍药苷（PF）是中药中的活性物质，常用于治疗皮肤炎症性疾病，但其作用机制尚不清楚。本研究探讨了GRb1和PF对炎症介质产生的影响，以及TRPV1在这些介质诱导中的可能机制。GRb1和PF抑制辣椒素（CAP）诱导的HaCaT细胞和HEK 293T-TRPV1细胞（TRPV1转基因过表达细胞）中IL-8和PGE(2)的产生，但对HEK 293T模拟细胞无影响(p
Ginsenoside Rb1 (GRb1) and paeoniflorin (PF) are active substances of Chinese traditional herbs and have been commonly used to treat skin inflammation diseases, but little is known about the mechanisms involved. In the present study, the effects of GRb1 and PF on the production of inflammatory mediators and the possible mechanisms of transient receptor potential vanilloid-1 (TRPV1) in these mediators induction were explored. It has been shown that GRb1 and PF inhibited the productions of IL-8 and PGE(2) induced by capsaicin (CAP) in HaCaT cells and HEK 293T-TRPV1 cells (which were transgenic and overexpressed TRPV1) but had no effect on HEK 293T mock cells (p