The homeobox gene Distal-less induces ventral appendage development in Drosophila
The homeobox gene Distal-less induces ventral appendage development in Drosophila
复制标题
DOI：
10.1101/gad.11.17.2259
复制
发表时间：
1997-09-01
影响因子：
10.5
通讯作者：
Guerrero, I
中科院分区：
文献类型：
--
作者：
Gorfinkiel, N;Morata, G;Guerrero, I
本研究探讨了同源异型盒基因Distal-less（Dll）在果蝇腿、触角和翅膀发育中的作用。缺乏Dll功能会导致腹侧附属物细胞（腿和触角）的身份发生变化，这通常会导致附属物的丢失。Dll在腹侧附属器近端区域的异位表达通过激活无翅和decapentaplegic诱导腿和触角的非自主复制。在背侧附属器中的异位Dll表达产生转化成相应的腹侧附属器;翅膀和笼头发育异位腿，并且头眼区域发育异位触角。在翅中，外源D11产物通过激活内源D11基因并抑制翅决定子基因残留来诱导这种转化。有人建议，Dll诱导腹侧附属物的发展，也参与了一个遗传地址，指定腹侧附属物的身份和歧视的背侧与腹侧附属物在成人。然而，与其他同源异型基因不同，Dll表达和功能不由细胞谱系边界限定。Dll还执行机翼正常模式所需的次要和后期功能。
This study investigates the role of the homeobox gene Distal-less (Dll) in the development of the legs, antennae, and wings of Drosophila. Lack of Dll function causes a change in the identity of ventral appendage cells (legs and antennae) that often results in the loss of the appendage. Ectopic Dll expression in the proximal region of ventral appendages induces nonautonomous duplication of legs and antennae by the activation of wingless and decapentaplegic. Ectopic Dll expression in dorsal appendages produces transformation into corresponding ventral appendages; wings and halteres develop ectopic legs and the head-eye region develops ectopic antennae. In the wing, the exogenous Dll product induces this transformation by activating the endogenous Dll gene and repressing the wing determinant gene vestigial. It is proposed that Dll induces the development of ventral appendages and also participates in a genetic address that specifies the identity of ventral appendages and discriminates the dorsal versus the ventral appendages in the adult. However, unlike other homeotic genes, Dll expression and function is not defined by a cell lineage border. Dll also performs a secondary and late function required for the normal patterning of the wing.