Baseline retinal vascular bed area on ultra-wide field fluorescein angiography correlates with the anatomical outcome of diabetic macular oedema to ranibizumab therapy: two-year analysis of the DAVE Study
Baseline retinal vascular bed area on ultra-wide field fluorescein angiography correlates with the anatomical outcome of diabetic macular oedema to ranibizumab therapy: two-year analysis of the DAVE Study
复制标题
超广角荧光素血管造影的基线视网膜血管床面积与雷珠单抗治疗糖尿病性黄斑水肿的解剖结果相关：DAVE 研究的两年分析
DOI：
10.1038/s41433-021-01777-7
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发表时间：
2022-03-24
期刊：
影响因子：
3.9
通讯作者：
Ip，Michael
中科院分区：
文献类型：
--
作者：
Fan，Wenying;Uji，Akihito;Ip，Michael
目的探讨超宽视场荧光素血管造影（UWF FA）视网膜基线非灌注面积（NPA）和视网膜血管床面积（RVBA）与糖尿病黄斑水肿（DMO）患者玻璃体内雷尼单抗治疗远期疗效的关系。方法采用事后2年观察性病例系列。在DAVE （NCT01552408）研究中，来自29名糖尿病患者和治疗naïve DMO的40只眼睛的基线UWF FA图像（Optos 200Tx）在Doheny图像阅读中心进行蒙太基和三维投影，以调整周围畸变。自动提取视网膜血管，计算RVBA。NPA由两名蒙面认证评分员手动划定。RVBA和NPA以mm2为单位自动计算，并与DMO的严重程度相关联。结果虽然基线时的全局NPA与视网膜厚度测量无关，但上视网膜的基线NPA与黄斑体积（MV）改善相关（P= 0.022）。多因素分析显示，在调整混杂因素后，基线时较小的RVBA与两年随访时较好的MV结果相关（P= 0.049）。结论基线RVBA较小的眼具有较好的DMO远期解剖效果。
PurposeTo determine the relationship between baseline retinal non-perfusion area (NPA) and retinal vascular bed area (RVBA) on ultra-wide field fluorescein angiography (UWF FA) and long-term response to intravitreal ranibizumab therapy in diabetic macular oedema (DMO).MethodsA post-hoc, 2-year observational case series. Baseline UWF FA images (Optos 200Tx) of 40 eyes from 29 patients with diabetes mellitus and treatment naïve DMO in the DAVE (NCT01552408) study were montaged and stereographically projected at the Doheny Image Reading Center to adjust for peripheral distortion. The retinal vasculature was automatically extracted to calculate RVBA. NPA was manually delineated by two masked certified graders. RVBA and NPA were computed in mm2automatically by adjusting for peripheral distortion and then correlated with the severity of DMO.ResultsWhile global NPA at baseline was not correlated to retinal thickness measurements, baseline NPA in the superior retina was associated with the macular volume (MV) improvement (P= 0.022). Multivariate analysis revealed a smaller RVBA at baseline was correlated with a better MV outcome at two-year follow-up after adjusting for confounding factors (P= 0.049).ConclusionEyes with smaller baseline RVBA appear to have a better long-term anatomic outcome of DMO.