Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines
Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines
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钯(II)催化的三组分串联环化反应一锅法组装4-芳基喹唑啉
DOI：
10.1055/s-0040-1707329
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发表时间：
2020-10-19
影响因子：
2.6
通讯作者：
Yu，Yongping
中科院分区：
文献类型：
--
作者：
Wang，Zijuan;Chen，Wenteng;Yu，Yongping
描述了一种一锅法，用于连接三种不同的组分，从而产生各种各样的4-芳基喹唑啉（27个例子），收率良好至优异。该方法包括钯（II）催化的级联反应，包括C(sp) -C （sp2）偶联，然后是分子内C - n键的形成。该反应很容易扩大到克量，并成功地应用于转运蛋白（TSPO）配体的合成。
A one-pot method for joining three separate components leading to an assortment of 4-arylquinazolines (27 examples) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed cascade reaction involving C(sp)–C(sp2) coupling followed by intramolecular C–N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator protein (TSPO) ligand.