Effect of macronutrient composition on postprandial peptide YY levels
Effect of macronutrient composition on postprandial peptide YY levels
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DOI：
10.1210/jc.2006-2273
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发表时间：
2007-10-01
影响因子：
5.8
通讯作者：
Nestler, John E.
中科院分区：
文献类型：
--
作者：
Essah, Paulina A.;Levy, James R.;Nestler, John E.
背景：肽YY（PYY）在餐后从远端小肠和结肠释放，并通过增加饱腹感来降低食欲。释放的PYY量与摄入的卡路里成比例。研究的目的是通过比较1周的体重维持低碳水化合物、高脂肪（LCHF）饮食与低脂肪、高碳水化合物（LFHC）饮食来确定大量营养素组合物是否影响餐后血清PYY水平。研究方法：在这项随机交叉研究中，18名肥胖受试者（14名女性，4名男性，平均体重指数为35.6 ± 2.9 kg/m2）被随机分配到1周的体重维持LCHF或LFHC饮食组，之后给予相同成分的试验餐，并在餐后2.5小时评估血清PYY水平。结果：1周后，LCHF试验餐后的平均餐后曲线下面积PYY是LFHC试验餐后的1.5倍（P <0.001）。与LFHC饮食相比，LCHF饮食导致餐后血清PYY水平高出55%（P = 0.005）。结论：这些数据表明，LCHF饮食刺激PYY分泌比LFHC饮食肥胖个体。
Background: Peptide YY ( PYY) is released from the distal small intestine and colon after meals and reduces appetite by increasing satiety. The amount of PYY released is proportional to calories ingested. Fat ingestion has also been reported to stimulate PYY release.Objective: The objective of the study was to determine whether macronutrient composition influences postprandial serum PYY levels by comparing 1 wk of a weight- maintenance low- carbohydrate, high-fat ( LCHF) diet with a low- fat, high- carbohydrate ( LFHC) diet. Methods: In this randomized crossover study, 18 obese subjects ( 14 females, 4 males, mean body mass index 35.6 +/- 2.9 kg/m(2)) were randomly assigned initially to 1 wk of a weight- maintenance LCHF or LFHC diet, after which a test meal of identical composition was given and serum PYY levels were assessed for 2.5 h postprandially. After a 1- wk washout period, subjects were crossed over and retested.Results: After 1 wk, mean postprandial area under the curve PYY after the LCHF test meal was 1.5- fold greater than after the LFHC test meal ( P < 0.001). The LCHF diet led to 55% higher levels of postprandial serum PYY levels, compared with the LFHC diet ( P = 0.005).Conclusions: These data show that a LCHF diet stimulates PYY secretion more than a LFHC diet in obese individuals.