The human corpus luteum: remodelling during luteolysis and maternal recognition of pregnancy
The human corpus luteum: remodelling during luteolysis and maternal recognition of pregnancy
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DOI：
10.1530/ror.0.0050012
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发表时间：
2000-01-01
期刊：
影响因子：
--
通讯作者：
Duncan, WC
中科院分区：
文献类型：
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作者：
Duncan, WC
与黄体溶解相关的显著组织重塑包括基质金属蛋白酶(MMPs)的表达和活性增加以及免疫细胞，特别是巨噬细胞的涌入。由于黄体表达高浓度的MMPs特异性组织抑制物，很明显，MMPs活性的增加不仅重要，而且它们的组织定位也很重要。人绒毛膜促性腺激素抑制早孕黄体中基质金属蛋白酶的表达和巨噬细胞的流入。然而，巨噬细胞和黄体中MMPs的主要细胞来源不表达LH-hCG受体。因此，在黄体溶解和母体识别妊娠的过程中，表达促黄体生成素受体的类固醇生成细胞的产物可能参与了对基质金属蛋白酶表达和巨噬细胞内流的不同旁分泌调节。
The marked tissue remodelling associated with luteolysis involves increased expression and activity of matrix metalloproteinases (MMPs) and an influx of immune cells, notably macrophages. Since the corpus luteum expresses high concentrations of specific tissue inhibitors of MMPs, it is clear that it is not only the increased activity of MMPs that is important, but also their tissue localization. Human chorionic gonadotrophin inhibits both MMP expression and macrophage influx in the rescued corpus luteum of early pregnancy. However, macrophages and the main cellular sources of MMPs in the corpus luteum do not express LH-hCG receptors. Therefore, it is likely that products of the steroidogenic cells, which do express LH-hCG receptors, are involved in the differential paracrine regulation of MMP expression and macrophage influx during luteolysis and maternal recognition of pregnancy.