Detecting Response of Rat C6 Glioma Tumors to Radiotherapy Using Hyperpolarized [1-13C]Pyruvate and 13C Magnetic Resonance Spectroscopic Imaging
Detecting Response of Rat C6 Glioma Tumors to Radiotherapy Using Hyperpolarized [1-13C]Pyruvate and 13C Magnetic Resonance Spectroscopic Imaging
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DOI：
10.1002/mrm.22698
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发表时间：
2011-02-01
影响因子：
3.3
通讯作者：
Brindle, Kevin M.
中科院分区：
文献类型：
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作者：
Day, Sam E.;Kettunen, Mikko I.;Brindle, Kevin M.
我们在此表明，超极化的[1-C-13]丙酮酸盐可用于检测神经胶质瘤模型中的治疗反应；一种肿瘤类型，使用正电子发射断层扫描检测 (18) 氟-2-脱氧葡萄糖的反应受到正常脑组织高背景信号的限制。向植入 C6 神经胶质瘤的大鼠静脉注射超极化 [1-C-13] 丙酮酸后获得的 C-13 化学位移图像显示，肿瘤内有显着的乳酸标记，但在周围大脑中水平相对较低。在大脑上方的血管和其他地方的其他主要血管中观察到标记的丙酮酸水平较高，但在肿瘤和大脑中仅检测到低水平。肿瘤乳酸中超极化 C-13 标记与血液中最大丙酮酸信号的比率15 Gy 全脑照射后 72 小时，血管数量从 0.38 +/- 0.16 减少至 0.23 +/- 0.13（减少 34%）。磁共振医学 65：557-563，2011。 (C) 2010 Wiley-Liss, Inc.
We show here that hyperpolarized [1-C-13]pyruvate can be used to detect treatment response in a glioma tumor model; a tumor type where detection of response with (18)fluoro-2-deoxyglucose, using positron emission tomography, is limited by the high background signals from normal brain tissue. C-13 chemical shift images acquired following intravenous injection of hyperpolarized [1-C-13]pyruvate into rats with implanted C6 gliomas showed significant labeling of lactate within the tumors but comparatively low levels in surrounding brain.Labeled pyruvate was observed at high levels in blood vessels above the brain and from other major vessels elsewhere but was detected at only low levels in tumor and brain.The ratio of hyperpolarized C-13 label in tumor lactate compared to the maximum pyruvate signal in the blood vessels was decreased from 0.38 +/- 0.16 to 0.23 +/- 0.13, (a reduction of 34%) by 72 h following whole brain irradiation with 15 Gy. Magn Reson Med 65:557-563,2011. (C) 2010 Wiley-Liss, Inc.