Plasma amyloid β-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease
Plasma amyloid β-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease
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DOI：
10.1001/archneur.65.6.776
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发表时间：
2008-06-01
影响因子：
--
通讯作者：
Irizarry, Michael C.
中科院分区：
文献类型：
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作者：
Locascio, Joseph J.;Fukumoto, Hiroaki;Irizarry, Michael C.
目的：检测淀粉样前体蛋白代谢的血浆标志物（以瓦尔-40 [A β 40]和Ala-42 [A β 42]结尾的淀粉样β蛋白），炎症（高敏C反应蛋白）和叶酸代谢（叶酸、维生素B-12和总同型半胱氨酸水平）与阿尔茨海默病患者认知和功能下降的速率相关。设计：纵向研究，平均值（SD）为4.2（2.6）年，每隔6- 12个月进行一次评估。设置：门诊护理。患者：一组122例临床诊断为可能的阿尔茨海默病的患者，每例患者在一段时间内至少进行2次评估。主要结果测量：幸福型痴呆量表的认知信息-记忆-注意力子量表得分和功能性Weintraub日常生活活动量表得分。低血浆A β 40、A β 42和高敏C反应蛋白水平与认知能力下降显著更快相关，如使用祝福痴呆量表所示，而不是高水平。低水平的A β 42和高敏感性C反应蛋白与Weintraub日常生活活动量表上的功能下降比高水平显著相关。这些血浆标志物贡献了约5%至12%的变异占祝福痴呆量表和日常生活活动量表的固定效应预测。叶酸代谢的措施没有与任何祝福痴呆量表或日常生活Scale.Conclusions的活动的变化：淀粉样前体蛋白代谢和C-反应蛋白的血浆标志物可能与阿尔茨海默病患者的认知和功能下降的速度。
Objective: To examine whether plasma markers of amyloid precursor protein metabolism (amyloid beta-protein ending in Val-40 [A beta 40] and Ala-42 [A beta 42]), inflammation (high-sensitivity C-reactive protein), and folic acid metabolism (folic acid, vitamin B-12, and total homocysteine levels) are associated with the rate of cognitive and functional decline in persons with Alzheimer disease.Design: Longitudinal study across a mean (SD) of 4.2 (2.6) years with assessments at approximately 6-to 12-month intervals.Setting: Outpatient care.Patients: A cohort of 122 patients having a clinical diagnosis of probable Alzheimer disease, each with at least 2 assessments across time.Main Outcome Measures: Scores on the cognitive Information-Memory- Concentration subscale of the Blessed Dementia Scale and the functional Weintraub Activities of Daily Living Scale.Results: Low plasma levels of A beta 40, A beta 42, and high-sensitivity C-reactive protein were associated with a significantly more rapid cognitive decline, as indexed using the Blessed Dementia Scale, than were high levels. Low levels of A beta 42 and high-sensitivity C-reactive protein were significantly associated with more rapid functional decline on the Weintraub Activities of Daily Living Scale than were high levels. These plasma markers contributed about 5% to 12% of the variance accounted for on the Blessed Dementia Scale and the Activities of Daily Living Scale by fixed-effects predictors. Measures of folic acid metabolism were not associated with changes on either the Blessed Dementia Scale or the Activities of Daily Living Scale.Conclusions: Plasma markers of amyloid precursor protein metabolism and C-reactive protein may be associated with the rate of cognitive and functional decline in patients with Alzheimer disease.