Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children
Imbalance of endogenous homocysteine and hydrogen sulfide metabolic pathway in essential hypertensive children
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原发性高血压儿童内源性同型半胱氨酸与硫化氢代谢途径失衡
DOI：
10.1097/00029330-200703010-00008
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发表时间：
2007-03-05
影响因子：
6.1
通讯作者：
Du Jun-bao
中科院分区：
文献类型：
--
作者：
Chen Li;Ingrid, Sumou;Du Jun-bao
背景高血压是心血管系统的常见病。到目前为止，原发性高血压的发病机制尚不清楚。对其发病机制的阐述是该领域亟待解决的重要课题。本研究旨在探讨高血压病患儿同型半胱氨酸(Hcy)和硫化氢(H_2S)代谢失衡及其在高血压发病机制中的意义。方法25例高血压病患儿和30例血压正常的健康儿童作为研究对象。对受试者进行病史调查和体格检查。荧光偏振免疫法测定血浆同型半胱氨酸含量。用硫化物电极改良法测定血浆H_2S水平。数据以平均值±标准差表示。对两组均值进行t检验。对血浆Hcy、H_2S及收缩压与H_2S/Hcy比值进行Pearson线性相关分析。结果与正常对照组比较，高血压病患者血浆内源性蛋氨酸途径的间歇性代谢产物同型半胱氨酸显著升高(P<0.01)，而该途径的最终产物H_2S显著降低(同型半胱氨酸：(12.68±9.69)&mGr；摩尔/L vs(6.62±4.79)；摩尔/L(t=2.996，P<0.01)；Mol/L)(t=-8.670，P<0.01)。高血压病患儿血浆H_2S/Hcy比值为5.83±2.91，对照组为11.60±3.30，t=-6.610，P<；血浆同型半胱氨酸与H_2S浓度呈负相关，r=-0.379，P<0.05。收缩压与血浆H_2S/Hcy比值呈负相关，r=-0.687，P<0.05。结论高血压病患儿存在同型半胱氨酸和硫化氢代谢失衡。
Background Hypertension is a common disease of the cardiovascular system. So far, the pathogenesis of primary hypertension remains unclear. The elaboration of its pathogenesis is an important topic in the field which calls for urgent resolution. The aim of this study was to probe into the metabolic imbalance of homocysteine (Hcy) and hydrogen sulfide (H2S) in children with essential hypertension, and its significance in the pathogenesis of essential hypertension. Methods Twenty‐five children with essential hypertension and 30 healthy children with normal blood pressure were enrolled in the study. The medical history was investigated and a physical examination was conducted on the subjects. Plasma Hcy content was examined by fluorescence polarization immunoassay (FPIA). The plasma H2S level was detected by a modified method with a sulfide electrode. Data were presented as mean ± standard deviation. The t test was applied to the mean values of both groups. Pearson linear correlation analysis was applied to the plasma Hcy and H2S as well as to the systolic pressure against the plasma H2S/Hcy ratio. Results Plasma Hcy, an intermittent metabolite of the endogenous methionine pathway, was markedly increased but plasma H2S, a final product of this pathway was significantly decreased in hypertensive cases when compared with normal subjects ((Hcy: (12.68 ±9.69) &mgr;mol/L vs (6.62 ±4.79) &mgr;mol/L (t=2.996, P<0.01); H2S: (51.93±6.01) &mgr;mol/L vs (65.70 ±5.50) &mgr;mol/L) (t=‐8.670, P<0.01)). The ratio of plasma H2S/Hcy in children with hypertension was 5.83 ±2.91, while that of the control group was 11.60 ±3.30, and the difference is significant with a t= ‐6.610 and P<0.01. A negative correlation existed between plasma Hcy and H2S concentrations, r=‐0.379, P<0.05. And a negative correlation was found between systolic blood pressure and the plasma H2S/Hcy ratio, r=‐0.687, P<0.05. Conclusion There was a metabolic imbalance of homocysteine and hydrogen sulfide in essential hypertensive children.