ABO blood group in relation to plasma lipids and proprotein convertase subtilisin/kexin type 9
ABO blood group in relation to plasma lipids and proprotein convertase subtilisin/kexin type 9
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DOI：
10.1016/j.numecd.2014.10.015
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发表时间：
2015-04-01
影响因子：
3.9
通讯作者：
Li, Jian-Jun
中科院分区：
文献类型：
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作者：
Li, Sha;Xu, Rui-Xia;Li, Jian-Jun
背景和目的：蛋白转化酶subtilisin/kexin type 9 （PCSK9）是一种新发现的成员，在胆固醇稳态中起重要作用，在高脂血症和冠状动脉疾病（CAD）的治疗中具有良好的前景。然而，PCSK9的决定因素尚未明确。ABO血型与胆固醇代谢有密切关系。因此，我们研究了ABO血型与血浆PCSK9水平的关系。方法和结果：一组507名连续接受诊断性或介入性冠状动脉造影的患者被纳入这项横断面研究。收集基线临床特征，采用ELISA检测血浆PCSK9水平。因此，非O型患者的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、非高密度脂蛋白胆固醇（NHDL-C）、载脂蛋白B （apo B）、PCSK9水平均高于O型患者（p < 0.05）。PCSK9水平与TC、LDL、NHDL-C、apo B呈显著正相关（r = 0.253, p < 0.001; r = 0.262, p < 0.001; r = 0.215, p < 0.001; r = 0.187, p < 0.001）。多变量回归分析显示，ABO血型与PCSK9水平有显著的独立相关性（β = 7.91, p = 0.009）。此外，中介分析表明，ABO血型对PCSK9水平的影响约8%-19%是由TC、LDL-C或NHDL-C水平介导的。结论：这些数据首次提示ABO血型可能是血浆PCSK9水平的重要决定因素。也有可能观察到PCSK9和ABO血型之间的关联可能部分参与了他们的CAD易感性。(C) 2014 Elsevier B.V.版权所有
Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9), a newly-identified member that plays an essential role in cholesterol homeostasis and holds decent promise for hyperlipidemia and coronary artery disease (CAD) treatment. However, the determining factors of PCSK9 are not well-characterized. It is well established that ABO blood group is associated with cholesterol metabolism. Therefore, the relationship between ABO blood groups and plasma PCSK9 level was examined.Methods and results: A group of 507 consecutive patients undergoing diagnostic or interventional coronary angiography were enrolled in this cross-sectional study. The baseline clinical characteristics were collected, and the plasma PCSK9 levels were determined using ELISA. As a result, subjects of non-O type had higher levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), non high density lipoprotein cholesterol (NHDL-C), apolipoprotein B (apo B), and PCSK9 compared with that of O type (p < 0.05, all). PCSK9 levels were significantly and positively related to TC, LDL, NHDL-C, and apo B (r = 0.253, p < 0.001; r = 0.262, p < 0.001; r = 0.215, p < 0.001; r = 0.187, p < 0.001; respectively). Multivariable regression analysis revealed that ABO group was significantly and independently associated with PCSK9 level (beta = 7.91, p = 0.009). Additionally, mediation analysis indicated that approximate to 8%-19% of the effect of ABO blood group on PCSK9 levels was mediated by TC, LDL-C or NHDL-C levels.Conclusions: These data firstly suggested that the ABO blood group might be a significant determinant factor for plasma PCSK9 level. It is also possible that the observed association between PCSK9 and ABO blood group might be in part involved in their CAD susceptibility. (C) 2014 Elsevier B.V. All rights reserved.