Molecular Pathology of Urothelial Carcinoma.
Molecular Pathology of Urothelial Carcinoma.
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尿路上皮癌的分子病理学研究。
DOI：
10.1016/j.path.2021.05.005
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发表时间：
2021-09
影响因子：
--
通讯作者：
Netto, George J
中科院分区：
文献类型：
--
作者：
Al-Ahmadie, Hikmat;Netto, George J
尿路上皮癌的特点是存在广泛的组织病理特征和分子改变，导致其形态和基因组异质性。它通常具有较高的体细胞突变率，具有相当大的基因组和转录复杂性和异质性，这反映了其不同的组织形态和临床特征。本文综述了尿路上皮癌的分子特征和新的分子分类以及变异组织学的最新进展。
Urothelial carcinoma is characterized by the presence of a wide spectrum of histopathologic features and molecular alterations that contribute to its morphologic and genomic heterogeneity. It typically harbors high rates of somatic mutations with considerable genomic and transcriptional complexity and heterogeneity that is reflective of its varied histomorphologic and clinical features. This review provides an update on the recent advances in the molecular characterization and novel molecular taxonomy of urothelial carcinoma and variant histologies.