Survival analysis of distant prostate cancer by decade (1973-1997) in the Detroit Metropolitan Surveillance, Epidemiology and End Results (SEER) Program registry: has outcome improved? (United States).
Survival analysis of distant prostate cancer by decade (1973-1997) in the Detroit Metropolitan Surveillance, Epidemiology and End Results (SEER) Program registry: has outcome improved? (United States).
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底特律大都会监测、流行病学和最终结果 (SEER) 计划登记处对远处前列腺癌十年（1973-1997）的生存分析：结果是否有所改善？
DOI：
10.1023/a:1025675303370
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Hussain,Maha
中科院分区：
文献类型：
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作者：
Barnholtz-Sloan,JillS;Severson,RichardK;Vaishampayan,Ulka;Hussain,Maha
目的：本研究的目的是探讨在生存诊断后的差异与遥远的阶段前列腺癌由decade of diagnosis.Methods：受试者是3337白种人和1947非洲裔美国男性与新诊断的原发性遥远的阶段前列腺癌之间的1973年和1997年，随访至2001年，从底特律SEER注册。计算每个感兴趣变量的每个类别中的男子比例。相对生存率用于检查随时间推移的生存模式。Kaplan-Meier和考克斯比例风险模型也被用来检查诊断的10年与短期（≤24个月）和长期（>24个月）生存的关系。不同种族的相对生存率相似，并随肿瘤分级的增加而降低。诊断后≤24个月的男性生存率随时间推移相似。然而，对于诊断后生存>24个月的男性，随着时间的推移，有显著差异（p< 0.0001）。然而，长期存活者（>24个月）是造成这种诊断十年生存率差异的主要因素。
Objective: The purpose of this study is to examine differences in survival after diagnosis with distant stage prostate cancer by decade of diagnosis.Methods: Subjects are 3337 Caucasian and 1947 African-American men with newly diagnosed primary distant stage prostate cancer between 1973 and 1997, with follow-up through 2001, from the Detroit SEER registry. The proportion of men within each category of each variable of interest is calculated. Relative survival is used to examine survival patterns over time. Kaplan–Meier and Cox proportional hazard models are also used to examine the relationship between decade of diagnosis and survival between short term (≤24 months) and long term (>24 months) survivors.Results: Relative survival has increased over the past three decades although this trend is not statistically significant. Relative survival is similar by race and decreases with increasing grade of tumor. Survival for men living ≤24 months after diagnosis is similar over time. However, for men living >24 months after diagnosis, there is a significant difference over time (p< 0.0001).Conclusion(s): In general, relative survival has been improving over the past three decades. However, it is the long term survivors (>24 months) that are the primary contributors to this difference in survival by decade of diagnosis.