Hedgehog and Spitz Making a Match between Photoreceptor Axons and Their Targets
Hedgehog and Spitz Making a Match between Photoreceptor Axons and Their Targets
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Hedgehog 和 Spitz 在感光器轴突与其目标之间进行匹配
DOI：
10.1016/s0092-8674(00)81627-x
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发表时间：
1998
期刊：
影响因子：
64.5
通讯作者：
S. Zipursky
中科院分区：
文献类型：
--
作者：
I. Salecker;T. R. Clandinin;S. Zipursky
感觉输入是如何与中枢神经系统中的信息处理结构相联系的？神经生物学中这个关键问题的部分答案在于形态学：感觉系统在感觉轴突和它们的靶神经元的数量之间显示出特征性的会聚比。虽然这些神经元的数量可以独立确定，但它们之间的相互作用对实现最终的布线模式至关重要。在许多系统中，这种协调是由来自靶细胞的逆行信号介导的，这些信号调节感觉神经元中的细胞死亡和增殖。相反，控制目标神经元数量的信号可以从传入轴突传递到下游细胞。例如，鱼类和青蛙视顶盖的增殖受向内生长的视网膜轴突调节，在大鼠嗅球中，生发细胞的细胞周期动力学受先驱性嗅觉轴突控制（例如，Davis 1990; Gong and Shipley 1995）。通过这种方式，感觉输入的程度与下游处理结构（目标神经元）的大小相匹配。最近对果蝇视觉系统的研究发现，Hedgehog（HH）和EGF样配体Spitz是两种众所周知的发育信号，它们是调节靶细胞增殖和分化的顺行信号（Huang and Kunes 1996; Huang and Kunes 1998; Huang et al. 1998 [this issue of Cell]）。
How is sensory input linked to the information processing structures in the central nervous system? Part of the answer to this key question in neurobiology lies in morphology: sensory systems display a characteristic convergence ratio between the number of sensory axons and their target neurons. While the number of these neurons could be independently determined, interactions between them are central to achieving the final wiring pattern. In many systems, this coordination is mediated by retrograde signals from target cells that regulate cell death and proliferation in the sensory neurons. Conversely, signals that control the number of target neurons can pass from afferent axons to downstream cells. For instance, proliferation in the optic tecta of fish and frogs is regulated by ingrowing retinal axons and, in the rat olfactory bulb, the cell cycle kinetics of germinal cells are controlled by pioneering olfactory axons (eg, Davis 1990; Gong and Shipley 1995). In this manner, the extent of sensory input is matched to the size of the downstream processing structures, the target neurons. Recent studies in the Drosophila visual system have led to the identification of two well-known developmental cues, Hedgehog (HH) and the EGF-like ligand Spitz, as anterograde signals that regulate the proliferation and differentiation of target cells (Huang and Kunes 1996; Huang and Kunes 1998; Huang et al. 1998 [this issue of Cell]).
果蝇中沿视网膜轴突传输的信号：刺猬信号接收和椎板盒组件的细胞电路。
DOI：
10.1242/dev.125.19.3753
发表时间：
1998
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Huang,Z;Kunes,S
通讯作者：
Kunes,S