Synaptic Cell Adhesion Molecules
Synaptic Cell Adhesion Molecules
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DOI：
10.1007/978-3-7091-0932-8_5
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Dityatev, Alexander
中科院分区：
文献类型：
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作者：
Bukalo, Olena;Dityatev, Alexander
在轴突寻路之后的神经系统发育期间，在神经元之间建立突触连接。特异性细胞粘附分子（CAM）聚集在突触前和突触后位点，并通过与细胞内和细胞外支架的相互作用触发突触分化。这些相互作用对于调整突触前和突触后转导机制以及将细胞与细胞粘附的位点偶联到细胞骨架和信号复合物是重要的，所述细胞骨架和信号复合物是积累和再循环突触前囊泡、胞外区和内吞区的组分以及突触后受体所必需的。在成熟的大脑中，CAM有助于调节突触功效和可塑性，部分通过与突触后神经递质受体和突触前电压门控离子通道的直接相互作用。本章将重点介绍突触CAM的主要类别，它们的多种功能，以及不同CAM与突触其他组件之间的多级协同相互作用。
During development of the nervous system following axon pathfinding, synaptic connections are established between neurons. Specific cell adhesion molecules (CAMs) accumulate at pre- and postsynaptic sites and trigger synaptic differentiation through interactions with intra- and extracellular scaffolds. These interactions are important to align pre- and postsynaptic transduction machineries and to couple the sites of cell-to-cell adhesion to the cytoskeleton and signaling complexes necessary to accumulate and recycle presynaptic vesicles, components of exo- and endocytic zones, and postsynaptic receptors. In mature brains, CAMs contribute to regulation of synaptic efficacy and plasticity, partially via direct interactions with postsynaptic neurotransmitter receptors and presynaptic voltage-gated ion channels. This chapter is to highlight the major classes of synaptic CAMs, their multiple functions, and the multistage concerted interactions between different CAMs and other components of synapses.