Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults
Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults
复制标题
DOI：
10.4269/ajtmh.2006.74.1078
复制
发表时间：
2006-06-01
影响因子：
3.3
通讯作者：
Gubler, Duane J.
中科院分区：
文献类型：
--
作者：
Kuniholm, Mark H.;Wolfe, Nathan D.;Gubler, Duane J.
来自黄病毒科、托加病毒科和布尼亚病毒科的虫媒病毒被怀疑在撒哈拉以南非洲人群中引起广泛的发病率，但很少有研究记录这些病原体的负担和分布。我们使用标准斑块减少中和试验（PRNT）对来自9个农村的256名喀麦隆成年人的血清样本进行了登革热-2 （dun -2）、西尼罗河（WN）、黄热病（YF）、基孔肯雅热（CHIK）、O’nyong-nyong （ONN）、辛德比斯病毒（SIN）和塔希纳病毒（TAH）感染检测。其中，DEN-2阳性12.5%，WN阳性6.6%，YF阳性26.9%，CHIK血清阳性46.5%，ONN阳性47.7%，SIN阳性7.8%，TAH阳性36.3%。居住在草屋顶或茅草屋顶的居民和远离城市中心的村庄的居民中，DEN-2、YF和CHIK的血清患病率较低。YF和CHIK的血清患病率随年龄增长而增加。这些结果表明，流行间虫媒病毒感染在中非人群中很常见。
Arboviruses from the families Flaviviridae, Togaviridae, and Bunyaviridae are suspected to cause widespread morbidity in sub-Saharan African populations, but little research been done to document the burden and distribution of these pathogens. We tested serum samples from 256 Cameroonian adults from nine rural villages for the presence of Dengue-2 (DEN-2), West Nile (WN), Yellow fever (YF), Chikungunya (CHIK), O'nyong-nyong (ONN), Sindbis (SIN), and Tahyna (TAH) infection using standard plaque-reduction neutralization tests (PRNT). Of these samples, 12.5% were DEN-2 positive, 6.6% were WN positive, 26.9% were YF positive, 46.5% were CHIK seropositive, 47.7% were ONN positive, 7.8% were SIN positive, and 36.3% were TAH positive. DEN-2, YF, and CHIK seroprevalence rates were lower among individuals living in dwellings with grass or thatched roofs versus corrugated tin and in villages isolated from urban centers. Seroprevalence rates of YF and CHIK increased with age. These results suggest that inter-epidemic arboviral infection is common in central African populations.