Cu(I)-catalyzed asymmetric allylation of ketones and ketimines
Cu(I)-catalyzed asymmetric allylation of ketones and ketimines
复制标题
DOI：
10.1351/pac200880051055
复制
发表时间：
2008-05-01
影响因子：
1.8
通讯作者：
Shibasaki, Masakatsu
中科院分区：
文献类型：
--
作者：
Kanai, Motomu;Wada, Reiko;Shibasaki, Masakatsu
报道了手性CuF催化的酮和酮亚胺的不对称烯丙化反应。在助催化剂[La((OPR)-Pr-I)(3)或(LiOPr)-Pr-I]的促进下，通过跨金属反应(烯丙基硼酸盐到烯丙基铜)的亲核活化是这些反应的关键。CuOTf-3KO(T)Bu-DUPHOS络合物是一种相对有效的催化剂，可以减少手性膦的用量。
Chiral CuF-catalyzed asymmetric allylation of ketones and ketimines is described. Nucleophile activation via transmetallation (allylboronate to allylcopper), which is facilitated by a cocatalyst [La((OPr)-Pr-i)(3) or (LiOPr)-Pr-i], is key for these reactions. A CuOTf-3KO(t)Bu-DUPHOS complex is a comparably effective catalyst that reduces the required amount of chiral phosphines.