Sequenced Reactions with Samarium(II) Iodide. Tandem Nucleophilic Acyl Substitution/Ketyl−Olefin Coupling Reactions
Sequenced Reactions with Samarium(II) Iodide. Tandem Nucleophilic Acyl Substitution/Ketyl−Olefin Coupling Reactions
复制标题
碘化钐(II) 串联亲核酰基取代/酮基-烯烃偶联反应。
DOI：
10.1021/ja952619k
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
C. Harris
中科院分区：
文献类型：
--
作者：
G. Molander;C. Harris
利用碘化钐促进了分子内亲核酰基取代/分子内烷基-烯烃偶联环化序列，生成了双环、三环和螺旋环体系，收率高，非对映选择性高。这种多用途的反应顺序允许进入几种不同的自然发生的三环系统，其中包含角和线性三醌框架。
Samarium(II) iodide has been employed to promote a tandem intramolecular nucleophilic acyl substitution/intramolecular ketyl−olefin coupling cyclization sequence, generating bicyclic, tricyclic, and spirocyclic ring systems in excellent yield and with high diastereoselectivity. This versatile reaction sequence allows entry to several different naturally occurring tricyclic systems containing the angular and linear triquinane framework.