High-field magnetic resonance imaging of structural alterations in first-episode, drug-naive patients with major depressive disorder.
High-field magnetic resonance imaging of structural alterations in first-episode, drug-naive patients with major depressive disorder.
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DOI：
10.1038/tp.2016.209
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发表时间：
2016-11-08
影响因子：
6.8
通讯作者：
Gong Q
中科院分区：
文献类型：
--
作者：
Chen Z;Peng W;Sun H;Kuang W;Li W;Jia Z;Gong Q
先前的结构成像研究发现了重度抑郁症（MDD）患者大脑形态变化的证据，但这些研究很少排除某些重要因素的复合影响，例如药物和长期患病。此外，MDD 患者结构改变的宏观发现的神经生物学机制仍不清楚。在这项研究中，我们利用磁化转移成像（脑组织大分子结构完整性的定量测量）来识别重度抑郁症患者的生物物理变化，这些变化以磁化转移比（MTR）表示。为了确定 MTR 变化是否独立于体积损失而发生，我们还进行了基于体素的形态测量（VBM）分析。参与者包括 27 名初治 MDD 患者和 28 名年龄和性别相匹配的健康对照者。基于全脑体素的分析用于比较各组的 MTR 和灰质体积，并分析 MTR 与年龄、症状严重程度和病程之间的相关性。与健康对照相比，MDD患者的左顶上小叶和左枕中回MTR显着降低，这可能与MDD患者的注意力和认知功能障碍有关。 VBM 分析显示 MDD 患者右侧中央后回灰质体积显着增加。这些在初治MDD患者中的发现可能反映了在疾病发作时，在容量损失之前存在的顶叶和枕叶皮质的微结构灰质变化，因此可能为抑郁症的早期神经生物学提供重要的新见解。
Previous structural imaging studies have found evidence of brain morphometric changes in patients with major depressive disorder (MDD), but these studies rarely excluded compounding effects of certain important factors, such as medications and long duration of illnesses. Furthermore, the neurobiological mechanism of the macroscopic findings of structural alterations in MDD patients remains unclear. In this study, we utilized magnetization transfer imaging, a quantitative measure of the macromolecular structural integrity of brain tissue, to identify biophysical alterations, which are represented by a magnetization transfer ratio (MTR), in MDD patients. To ascertain whether MTR changes occur independent of volume loss, we also conduct voxel-based morphometry (VBM) analysis. The participants included 27 first-episode, drug-naive MDD patients and 28 healthy controls matched for age and gender. Whole-brain voxel-based analysis was used to compare MTR and gray matter volume across groups and to analyse correlations between MTR and age, symptom severity, and illness duration. The patients exhibited significantly lower MTR in the left superior parietal lobule and left middle occipital gyrus compared with healthy controls, which may be related to the attentional and cognitive dysfunction in MDD patients. The VBM analysis revealed significantly increased gray matter volume in right postcentral gyrus in MDD patients. These findings in first-episode, drug-naive MDD patients may reflect microstructural gray matter changes in the parietal and occipital cortices close to illness onset that existed before volume loss, and thus potentially provide important new insight into the early neurobiology of depression.