Sex differences in long-term smoking cessation rates due to nicotine patch
Sex differences in long-term smoking cessation rates due to nicotine patch
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DOI：
10.1080/14622200802097506
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发表时间：
2008-01-01
影响因子：
4.7
通讯作者：
Scott, John
中科院分区：
文献类型：
--
作者：
Perkins, Kenneth A.;Scott, John
与男性相比，女性可能更容易患上与吸烟有关的疾病，戒烟也更困难。药物反应的性别差异可以指导戒烟治疗，以提高女性的戒烟率。我们对14项安慰剂对照尼古丁贴片试验（N= 6，250）进行了荟萃分析，这些试验的长期（6个月）临床结局结果可按性别分别确定。这项分析更新了对其中11项试验的荟萃分析，这些试验发现尼古丁贴片没有显著的性别差异。尼古丁贴片与安慰剂贴片相比，女性戒烟率的增加只有男性的一半。尼古丁和安慰剂贴剂6个月时的合并绝对戒烟率分别为男性20.1%和10.8%，女性14.7%和10.1%。女性（OR=1.61）因尼古丁与安慰剂贴剂戒烟的比值比低于男性（OR=2.20），相互作用比值比为1.40（95% CI=1.02-1.93，p= 0.04）。这种性别差异并没有显着差异是否提供正式的咨询。使用尼古丁贴片治疗的女性与男性的有效结局表明，增加女性吸烟者的戒烟率可能需要补充贴片治疗或使用其他药物。
Compared to men, women may be at greater risk for smoking-related diseases and have greater difficulty quitting smoking. Sex differences in medication response could guide treatment for smoking cessation to improve women's quit rates. We conducted a meta-analysis of the 14 placebo-controlled nicotine patch trials (N=6,250) for which long-term (6 months) clinical outcome results could be determined separately by sex. This analysis updated a meta-analysis of 11 of these trials that found no significant sex differences due to nicotine patch. The increase in quitting due to the nicotine vs. placebo patch was only about half as large in women as in men. Pooled absolute quit rates at 6 months for nicotine and placebo patch, respectively, were 20.1% and 10.8% in men, and 14.7% and 10.1% in women. The odds ratio for quitting due to nicotine vs. placebo patch was lower in women (OR=1.61) than in men (OR=2.20), with an interaction odds ratio of 1.40 (95% CI=1.02-1.93, p=.04). This sex difference did not vary significantly by whether or not formal counseling was provided. Poorer outcomes in women vs. men treated with nicotine patch suggests that increasing the quit rates of women smokers may require supplementing patch treatment or use of other medications.