The effects of drugs on the production and recovery processes of the stress ulcer.
The effects of drugs on the production and recovery processes of the stress ulcer.
复制标题
药物对应激性溃疡产生和恢复过程的影响。
DOI：
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复制
发表时间：
1968
期刊：
影响因子：
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通讯作者：
Susumu Okabe
中科院分区：
文献类型：
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作者：
Keijiro Takagi;Susumu Okabe
关于抗溃疡药物的生物活性测定已报道了各种方法。大鼠幽门结扎（1-3）、大鼠束缚（4，5）、束缚大鼠水浸（7）和对各种动物应用致溃疡剂（8-11）用于产生实验性溃疡。在这些方法中，在溃疡产生之前对动物给药，并检测对溃疡产生过程的预防作用。近年来，虽然一些药物如谷氨酰胺或甲基蛋氨酸氯化硫铵等被用于促进已有溃疡的修复，但缺乏合适的药理试验方法，因此人们希望开发一种新的药物治疗已有溃疡的药理活性测定方法。本文报道了几种药物对大鼠应激性溃疡的治疗作用。
Various procedures have been reported on the biossay of antiulcer drugs . Pylorus ligation of the rat (1-3), restraint of the rat (4, 5), water immersion of the restrained rat (7) and the application of ulcerogenic agents on various animals (8-11) were used for producing experimental ulcers. In these methods the drug had been administered to the animal before the ulcer production and the preventive effect on the ulcer producing processes was tested. Although some drugs such as glutamine or methylmethionine sulfonium chloride were recently introduced to promote the repair of the ulcer which had existed already, suitable methods are lacking for their pharmacological test, and so it was hoped to develop a new method for pharmacological assay of curative activity of the drugs on existing ulcers. In the present paper curative effects of some drugs on the stress ulcer of the rat are reported.