Developments in Photoredox/Nickel Dual-Catalyzed 1,2-Difunctionalizations
Developments in Photoredox/Nickel Dual-Catalyzed 1,2-Difunctionalizations
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DOI：
10.1016/j.chempr.2020.05.013
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发表时间：
2020-06-11
期刊：
影响因子：
23.5
通讯作者：
Molandert, Gary A.
中科院分区：
文献类型：
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作者：
Badir, Shorouk O.;Molandert, Gary A.
在Ni/光氧化还原双催化方面的进展使得能够在非常温和的反应条件下在不同官能团的存在下构建C（sp（3））杂化中心。然而，这些策略主要限于一个C-C或C-杂原子键的组装，因为竞争性的双组分反应和从烷基金属络合物中容易的β-氢化物消除。最近，光诱导镍催化的烯烃和炔烃的1，2-双官能化反应吸引了广泛的研究努力，因为它们允许从廉价的起始材料在一锅中构建两个连续的化学键。在此，我们探讨了最新的进展，陈述了当前的挑战，并讨论了新催化系统设计的前景。
Progress in Ni/photoredox dual catalysis has enabled the construction of C(sp(3))-hybridized centers under extremely mild reaction conditions in the presence of diverse functional groups. These strategies, however, are mainly restricted to the assembly of one C-C or C-heteroatom linkage because of the competitive two-component reactions and facile beta-hydride elimination from alkylmetal complexes. Recently, photoinduced nickel-catalyzed 1,2-difunctionalizations of alkenes and alkynes have attracted extensive research efforts because they allow the construction of two sequential chemical bonds from inexpensive starting materials in one pot. Herein, we explore recent advances, state the current challenges, and discuss perspectives on the design of new catalytic systems.