Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction.
Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction.
复制标题
骨髓间充质干细胞对心肌梗死的修复机制
DOI：
10.1111/j.1582-4934.2010.01255.x
复制
发表时间：
2011-05
影响因子：
5.3
通讯作者：
Wang T
中科院分区：
文献类型：
--
作者：
Wen Z;Zheng S;Zhou C;Wang J;Wang T
尽管在最佳医学治疗和介入程序方面取得了进展，但心肌梗死（MI）和由此导致的慢性心力衰竭患者的预后仍然极差。心肌梗死后使用成体干细胞治疗的动物实验和临床试验显示了心肌功能的全面改善。骨髓间充质干细胞（MSCs）由于其多谱系、自我更新和增殖潜力，有望用于MI后的心脏修复。此外，MSC可以容易地分离，在培养中扩增，并且对宿主组织具有免疫豁免特性。实验研究和临床试验表明，骨髓间充质干细胞不仅可以分化为心肌细胞和血管细胞，还可以分泌大量的生长因子和细胞因子，通过激活驻留的心脏干细胞和其他干细胞介导内源性再生，并以旁分泌方式诱导新生血管形成、抗炎、抗凋亡、抗重构和心肌收缩。也有人推测，MSC的抗心肌炎和心脏神经发芽潜力可能有助于其在心脏修复中的有益作用。目前，心肌梗死后MSC治疗的分子和细胞机制尚不清楚。本文就骨髓间充质干细胞在心肌梗死中的修复机制作一综述。
The prognosis of patients with myocardial infarction (MI) and resultant chronic heart failure remains extremely poor despite advances in optimal medical therapy and interventional procedures. Animal experiments and clinical trials using adult stem cell therapy following MI have shown a global improvement of myocardial function. Bone marrow-derived mesenchymal stem cells (MSCs) hold promise for cardiac repair following MI, due to their multilineage, self-renewal and proliferation potential. In addition, MSCs can be easily isolated, expanded in culture, and have immunoprivileged properties to the host tissue. Experimental studies and clinical trials have revealed that MSCs not only differentiate into cardiomyocytes and vascular cells, but also secrete amounts of growth factors and cytokines which may mediate endogenous regeneration via activation of resident cardiac stem cells and other stem cells, as well as induce neovascularization, anti-inflammation, anti-apoptosis, anti-remodelling and cardiac contractility in a paracrine manner. It has also been postulated that the anti-arrhythmic and cardiac nerve sprouting potential of MSCs may contribute to their beneficial effects in cardiac repair. Most molecular and cellular mechanisms involved in the MSC-based therapy after MI are still unclear at present. This article reviews the potential repair mechanisms of MSCs in the setting of MI.
登录
查看更多内容
影响因子：
20.1
作者：
Hatzistergos KE;Quevedo H;Oskouei BN;Hu Q;Feigenbaum GS;Margitich IS;Mazhari R;Boyle AJ;Zambrano JP;Rodriguez JE;Dulce R;Pattany PM;Valdes D;Revilla C;Heldman AW;McNiece I;Hare JM
通讯作者：
Hare JM
影响因子：
37.8
作者：
Chang, MG;Tung, L;Abraham, R
通讯作者：
Abraham, R
影响因子：
5.2
作者：
Grauss, Robert W.;van Tuyn, John;Atsmaa, Douwe E.
通讯作者：
Atsmaa, Douwe E.
影响因子：
5.2
作者：
Gnecchi, Massimiliano;He, Huamei;Melo, Luis G.;Noiseaux, Nicolas;Morello, Fulvio;de Boer, Rudolf A.;Zhang, Lunan;Pratt, Richard E.;Dzau, Victor J.;Ingwall, Joanne S.
通讯作者：
Ingwall, Joanne S.
影响因子：
20.3
作者：
Aggarwal, S;Pittenger, MF
通讯作者：
Pittenger, MF