Oxygen vacancy confined nickel cobaltite nanostructures as an excellent interface for the enzyme-free electrochemical sensing of extracellular H2O2secreted from live cells
Oxygen vacancy confined nickel cobaltite nanostructures as an excellent interface for the enzyme-free electrochemical sensing of extracellular H2O2secreted from live cells
复制标题
氧空位限制的镍钴矿纳米结构作为活细胞分泌的细胞外 H(2)O(2) 无酶电化学传感的优异界面
DOI：
10.1039/d0nj03281f
复制
发表时间：
2020-09-07
影响因子：
3.3
通讯作者：
Chen, Wei
中科院分区：
文献类型：
--
作者：
Balasubramanian, Paramasivam;He, Shao-Bin;Chen, Wei
氧空位（O-V）的制备是提高催化剂效率的有效途径，因此，富O-V催化剂的开发吸引了大量的研究兴趣。在此，作者报道了具有丰富氧空位的高效NiCo（2）O（4）纳米结构（O-V-NCO）的工程。通过X射线光电子显微镜（XPS）和电子自旋共振谱（ESR）证实了O（V）的存在。阻抗分析证实，在NCO晶格中的氧空位制造有意义地促进界面电子转移。结果表明，O-V-NCO可以显著改善电催化性能。利用O-V-NCO的高氧空位、高比表面积和协同效应，制备了一种高效、可靠的非酶电化学H2O检测器。该传感器不仅表现出宽的线性响应（26-6.6 mM）与纳摩尔检测限（9 nM），但也对H2 O2的高选择性。通过实时监测RAW 264.7细胞中H2 O2的释放验证了该传感器的实用性，证实了该传感器在临床分析中的潜在应用。
Oxygen vacancy (O-V) manufacturing is an effective way to boost the efficiency of a catalyst; therefore, the development of O-V-rich catalysts has attracted substantial research interest. Herein, the authors report the engineering of highly efficient NiCo(2)O(4)nanostructures (O-V-NCO) with plentiful oxygen vacancies. The presence of O(V)was confirmed by X-ray photoelectron microscopy (XPS) and electron spin resonance spectroscopy (ESR). Impedance analysis confirmed that oxygen vacancy manufacturing in the NCO lattice meaningfully promotes the interfacial electron transferability. As a result, O-V-NCO could deliver improved electrocatalysis significantly. Furthermore, O-V-NCO was used to fabricate a highly efficient and dependable nonenzymatic electrochemical H(2)O(2)detector that achieved excellent sensing performance owing to the oxygen vacancy richness, high specific surface area and synergistic effects of O-V-NCO. The sensor not only exhibited a wide linear response (26-6.6 mM) with a nanomolar limit of detection (9 nM) but also a high selectivity for H2O2. The practicability of this resultant sensor was verified by real-time monitoring of H(2)O(2)release from RAW 264.7 cells, confirming the potential application of this biosensor in clinical analysis.