The influence of age and gender on the population-based incidence of community-acquired pneumonia caused by different microbial pathogens
The influence of age and gender on the population-based incidence of community-acquired pneumonia caused by different microbial pathogens
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DOI：
10.1016/j.jinf.2005.11.006
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发表时间：
2006-09-01
影响因子：
28.2
通讯作者：
Martin-Hidalgo, Alberto
中科院分区：
文献类型：
--
作者：
Gutierrez, Felix;Masia, Mar;Martin-Hidalgo, Alberto
目的：确定成人社区获得性肺炎(CAP)的人群发病率，评估年龄和性别对不同病原体感染发病率的相对重要性。方法：在西班牙地中海沿岸一个明确的地理区域进行为期两年的前瞻性研究。结果：社区获得性肺炎的总发病率为12例(95%可信区间11.25~13.45)/万人年。发病率随着年龄的增长而增加(P<；0.0001)，配偶的发病率更高(每10,000人年有16例对9例；P<；0.0001)。在75岁的配偶中，这一比例尤其高(每10,000人年中有87例)。肺炎球菌肺炎的发病率随着年龄的增长而显著增加，在75岁以上的人群中尤其高(每10,000人年有10例)。与年轻人相比，高龄人群与流感病毒相关的CAP发病率也高出15倍，衣原体感染的发病率高出5倍。嗜肺军团菌感染的发病率也随着年龄的增长而增加，配偶的发病率是男性的10倍。而肺炎支原体肺炎的发病率与年龄、性别无关。结论：年龄和性别对CAP的总体发病率和主要病原菌肺炎的发病率有较大影响，主要病原菌不仅包括肺炎链球菌，还包括流感病毒、衣原体等。和嗜肺性乳杆菌。年龄与肺炎链球菌、流感病毒和衣原体感染肺炎的风险有关，而配偶性别则大大增加了肺炎链球菌和衣原体的发病率。(C)2005年英国感染学会。爱思唯尔有限公司出版。保留所有权利。
Objectives: To determine the population-based incidence of community-acquired pneumonia (CAP) in adults and to assess the relative importance of age and gender on the incidence of infections caused by different microbial pathogens.Methods: A two-year prospective study in a well-defined geographic area of the Spanish Mediterranean coast.Results: The overall incidence rate of CAP was 12 cases (95% CI 11.25-13.45) per 10,000 person-years. Incidence rates increased by age (p < 0.0001) and they were higher in mates (16 versus 9 cases per 10,000 person-years; p < 0.0001). The rate was especially high among mates aged >75 years (87 cases per 10,000 person-years). The incidence of pneumococcal pneumonia increased significantly with ageing and it was particularly high among people aged >75 years (10 cases per 10,000 person-years). Very elderly people had also a 15-fold higher incidence of CAP associated with influenza virus and a 5-fold higher incidence of infections by Chlamydophila spp., than young adults. The incidence of infections with Legionella pneumophila also increased with age and it was 10 times higher in mates. In contrast, the incidence of pneumonia caused by Mycoplasma pneumoniae was unrelated to age and gender.Conclusions: Age and gender have a strong influence on the overall incidence of CAP and on the incidence of pneumonia caused by the main microbial pathogens, including not only Streptococcus pneumoniae, but also influenza virus, Chlamydophila spp. and L. pneumophila. Ageing is associated with a higher risk of acquiring pneumonia by S. pneumoniae, influenza virus and Chlamydophila spp., whereas mate gender increases greatly the incidence of L. pneumophila and Chlamydophila spp. (C) 2005 The British Infection Society. Published by Elsevier Ltd. All rights reserved.