Gold nanoparticles inhibit the proliferation of multiple myeloma cells
Gold nanoparticles inhibit the proliferation of multiple myeloma cells
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DOI：
10.1002/adma.200602098
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发表时间：
2007-03-05
影响因子：
29.4
通讯作者：
Mukherjee, Priyabrata
中科院分区：
文献类型：
--
作者：
Bhattacharya, Resham;Patra, Chitta Ranjan;Mukherjee, Priyabrata
金纳米颗粒以剂量依赖性方式显著抑制多发性骨髓瘤细胞系的增殖（见图）。金处理的多发性骨髓瘤细胞通过上调细胞周期蛋白依赖性激酶抑制剂蛋白p21和p27而在G1期（染色体准备复制的阶段）显示细胞周期停滞。金纳米粒子不影响正常的外周血单个核细胞。
Gold nanoparticles significantly inhibit proliferation in multiple myeloma cell lines (see figure) in a dose-dependent manner. Gold-treated multiple myeloma cells show cell-cycle arrest in the G1-phase (the phase when chromosomes prepare for replication) by up-regulation of cell-cycle cyclin-dependent kinase inhibitor proteins p21 and p27. Gold nanoparticles do not affect normal peripheral blood mononuclear cells.