RhoA/Rho kinase in spinal cord injury.
RhoA/Rho kinase in spinal cord injury.
复制标题
RhoA/Rho激酶在脊髓损伤中的作用
DOI：
10.4103/1673-5374.169601
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发表时间：
2016-01
影响因子：
6.1
通讯作者：
Xu XM
中科院分区：
文献类型：
--
作者：
Wu X;Xu XM
脊髓损伤是指由创伤而不是疾病引起的脊髓损伤。脊髓损伤包括原发性机械损伤和更复杂的继发性损伤过程，包括炎症、氧化、兴奋性毒性和细胞死亡。在脊髓继发性损伤过程中，多种信号通路被激活，在脊髓损伤的发病机制中起重要作用。其中，RhoA/Rho激酶通路在介导脊髓变性和再生中起着特殊的作用。本文就RhoA/Rho激酶在脊髓损伤中的作用和机制，以及RhoA/Rho激酶作为神经保护和轴突再生的靶点的可能性进行综述。
A spinal cord injury refers to an injury to the spinal cord that is caused by a trauma instead of diseases. Spinal cord injury includes a primary mechanical injury and a much more complex secondary injury process involving inflammation, oxidation, excitotoxicity, and cell death. During the secondary injury, many signal pathways are activated and play important roles in mediating the pathogenesis of spinal cord injury. Among them, the RhoA/Rho kinase pathway plays a particular role in mediating spinal degeneration and regeneration. In this review, we will discuss the role and mechanism of RhoA/Rho kinase-mediated spinal cord pathogenesis, as well as the potential of targeting RhoA/Rho kinase as a strategy for promoting both neuroprotection and axonal regeneration.