Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer.
Dysregulated Expression of Long Noncoding RNAs in Ovarian Cancer.
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DOI：
10.1097/igc.0000000000000828
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发表时间：
2016-11
期刊：
影响因子：
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通讯作者：
Peng S
中科院分区：
文献类型：
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作者：
Zhong Y;Gao D;He S;Shuai C;Peng S
卵巢癌是妇科恶性肿瘤妇女死亡的主要原因。卵巢癌的发展和进展是复杂的，是一个多步骤的过程。用于诊断和预后的新生物标志物分子对于新的治疗靶点和延长卵巢癌患者的生存时间至关重要。长链非编码RNA（longnoncodingRNA，lncRNA）是一类长度超过200个核苷酸的非蛋白质编码转录物，近年来被发现是多种生物学过程的关键调控因子，参与了包括癌症在内的多种疾病的发生和发展。本文就HOTAIR、H19、XIST和HOST 2等lncRNA的表达模式及其在卵巢癌发生发展中的作用机制进行综述。lncRNA作为生物标志物可用于当前和未来的临床诊断、治疗和预后。
Ovarian cancer is the leading cause of death among women with gynecologic malignancies. The development and progression of ovarian cancer are complex and a multiple-step process. New biomarker molecules for diagnostic and prognostic are essential for novel therapeutic targets and to extend the survival time of patients with ovarian cancer. Long noncoding RNAs (lncRNAs) are non–protein-coding transcripts longer than 200 nucleotides that have recently been found as key regulators of various biological processes and to be involved in the development and progression of many diseases including cancers. In this review, we summarized the expression pattern of several dysregulated lncRNAs (HOTAIR, H19, XIST, and HOST2) and the functional molecular mechanism of these lncRNAs on the initiation and progression of ovarian cancer. The lncRNAs as biomarkers may be used for current and future clinical diagnosis, therapeutics, and prognosis.