Vialinin A, a novel potent inhibitor of TNF-α production from RBL-2H3 cells
Vialinin A, a novel potent inhibitor of TNF-α production from RBL-2H3 cells
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DOI：
10.1248/bpb.31.831
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发表时间：
2008-05-01
影响因子：
2
通讯作者：
Yoshikawa, Kunie
中科院分区：
文献类型：
--
作者：
Onose, Jun-ichi;Xie, Chun;Yoshikawa, Kunie
Thelephora vialis是一种蘑菇，与中国云南的松树共生，云南是世界上最丰富和最多样化的生物资源。由于其风味，这是最受欢迎的食用蘑菇之一。我们从这些蘑菇中筛选生物活性化合物，分离出一种新的有效的抗氧化剂，vialinin A，以及已知的化合物，从T vialis的干燥子实体。Vialinin A是一种三联苯衍生物，通过光谱和化学方法进行了鉴定。Vialinin A显示出抗过敏活性，抑制β-氨基己糖苷酶、肿瘤坏死因子-α白细胞介素4和单核细胞趋化蛋白1从RBL-2 H3细胞释放，而atromentin和一种不可分离的ganbajunins D和E的混合物没有显示出这样的作用。Vialinin A显示出对RBL-2 H3细胞TNF-α产生的强效抑制作用（IC 50，0.09 +/- 0.01 nM），表明对器官移植的抑制作用强于他克莫司（IC 50，0.25 +/- 0.03 nM）。这些化合物对TNF-α产生的有效抑制活性表明有希望的抗过敏剂的新候选物。
Thelephora vialis is a mushroom that grows in symbiosis with pine trees in Yunnan, China, a place known to have some of the richest and most diverse bioresources in the world. This is one of the most favored edible mushrooms, due to its flavor. Our screening for bioactive compounds from these mushrooms isolated a novel potent antioxidant, vialinin A, together with known compounds, from the dry fruiting bodies of T vialis. Vialinin A is a terphenyl derivative and was elucidated by spectroscopic and chemical methods. Vialinin A showed anti-allergic activities, inhibition of beta-hexosaminidase, tumor necrosis factor TNF-alpha interleukin 4 and monocyte chemotactic protein 1 release from RBL-2H3 cells, whereas atromentin and an inseparable mixture of ganbajunins D and E showed no such effects. Vialinin A displayed potent inhibition of TNF-alpha production from RBL-2H3 cells (IC50, 0.09 +/- 0.01 nM), indicating stronger inhibition than tacrolimus for organ transplantation (IC50, 0.25 +/- 0.03 nM). The potent inhibitory activities of these compounds against TNF-alpha production indicate promising new candidates for anti-allergic agents.