Phthalate Concentrations in Personal Care Products and the Cumulative Exposure to Female Adults and Infants in Shanghai
Phthalate Concentrations in Personal Care Products and the Cumulative Exposure to Female Adults and Infants in Shanghai
复制标题
上海个人护理产品中邻苯二甲酸盐的浓度及女性成人和婴儿的累积暴露量
DOI：
10.1080/15287394.2014.968696
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发表时间：
2015-03-04
影响因子：
2.6
通讯作者：
Chen, Bo
中科院分区：
文献类型：
--
作者：
Bao, Jiaqin;Wang, Min;Chen, Bo
邻苯二甲酸酯 (PE) 是工业中广泛使用的合成化学品，已在个人护理产品 (PCP) 中检测到。最近的人类报告发现表明，与邻苯二甲酸盐暴露相关的内分泌干扰作用。本研究的目的是 (1) 测量从上海零售市场收集的 198 份 PCP 中 11 PE 的水平，以及 (2) 评估成年女性和婴儿的每日皮肤接触情况。利用危害指数 (HI) 方法进一步评估了累积暴露于八种 PE 对因皮肤使用 PCP 而产生的生殖系统功能的健康风险。邻苯二甲酸二乙酯 (DEP) 是最常检测到的化合物 (29.8%)，其次是邻苯二甲酸二异丁酯 (DiBP) (6.6%)。成年女性每日接触 DEP、邻苯二甲酸二（2-甲氧基乙基）酯（DMEP）、DiBP、邻苯二甲酸二丁酯（DBP）、邻苯二甲酸二苯酯（DPP）和邻苯二甲酸二（2-乙基己酯）（DEHP）的几何平均（GM）浓度分别为 0.018、0.012、0.002、0.001、0.003 和分别为0.002μg/kg体重(bw)/d。婴儿和成年女性的 GM 每日 PE 暴露水平相似，但婴儿中的 DEHP 较高。无论是在 GM 水平还是在最大水平，DEP 暴露在两个亚群中均最高。 8个PE的HI均远小于1，范围为0.0002至0.005，表明这些人群不存在累积生殖风险。 DBP、DMEP 和 DEHP 是累积 HI 的三个主要贡献者。综上所述，上海零售市场五氯苯酚中的邻苯二甲酸盐含量对中国成年女性和婴儿没有造成明显的累积风险。
Phthalate esters (PE) are synthetic chemicals widely used in industry, and have been detected in personal care products (PCP). Recent findings of human reports demonstrated endocrine-disrupting action associated with phthalate exposures. The aims of this study were to (1) measure levels of 11 PE in 198 PCP collected from retail markets in Shanghai and (2) assess daily dermal exposure in adult females and infants. The health risk of cumulative exposure to eight PE on reproductive system function derived from dermal PCP use was further assessed by utilizing the hazard index (HI) approach. Diethyl phthalate (DEP) was the most frequently detected compound (29.8%), followed by diisobutyl phthalate (DiBP) (6.6%). The geometric mean (GM) concentrations of daily exposure to DEP, bis(2-methoxyethyl) phthalate (DMEP), DiBP, dibutyl phthalate (DBP), diphenyl phthalate (DPP), and bis(2-ethylhexyl) phthalate (DEHP) in female adults were 0.018, 0.012, 0.002, 0.001, 0.003, and 0.002 mu g/kg body weight (bw)/d, respectively. The GM daily exposure levels to PE in infants and adult females were similar except for DEHP, which was higher in infants. DEP exposure was highest in both subpopulations at either GM or maximal level. All HI of 8 PE were far less than 1, ranging from 0.0002 to 0.005, indicating no cumulative reproductive risks to these populations. DBP, DMEP, and DEHP were three major contributors to the cumulative HI. In summary, the level of phthalate in PCP from Shanghai retail markets posed no apparent cumulative risk to adult females and infants in China.