2010 ACVIM small animal consensus statement on leptospirosis: diagnosis, epidemiology, treatment, and prevention.
2010 ACVIM small animal consensus statement on leptospirosis: diagnosis, epidemiology, treatment, and prevention.
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DOI：
10.1111/j.1939-1676.2010.0654.x
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发表时间：
2011-01
影响因子：
2.6
通讯作者：
Goldstein RE
中科院分区：
文献类型：
--
作者：
Sykes JE;Hartmann K;Lunn KF;Moore GE;Stoddard RA;Goldstein RE
本报告对犬钩端螺旋体病的诊断、流行病学、治疗和预防提供了一致意见。犬钩端螺旋体病的临床体征与肾脏疾病、肝脏疾病、葡萄膜炎和肺出血的发展有关。疾病可能伴随着高降雨量的时期，并且可能发生在靠近水源，农场动物或野生动物或居住在郊区环境中的狗漫游的狗中。诊断是基于急性和恢复期抗体滴度的显微镜凝集试验（MAT），有或没有使用聚合酶链反应测定。MAT结果存在相当大的实验室间差异，MAT不能准确预测感染血清群。从肾小管中最佳清除微生物的推荐治疗是强力霉素，5 mg/kg PO q12 h，持续14天。每年接种疫苗可预防由疫苗中包含的血清型引起的钩端螺旋体病，建议有感染风险的犬只接种。
This report offers a consensus opinion on the diagnosis, epidemiology, treatment, and prevention of leptospirosis in dogs, an important zoonosis. Clinical signs of leptospirosis in dogs relate to development of renal disease, hepatic disease, uveitis, and pulmonary hemorrhage. Disease may follow periods of high rainfall, and can occur in dogs roaming in proximity to water sources, farm animals, or wildlife, or dogs residing in suburban environments. Diagnosis is based on acute and convalescent phase antibody titers by the microscopic agglutination test (MAT), with or without use of polymerase chain reaction assays. There is considerable interlaboratory variation in MAT results, and the MAT does not accurately predict the infecting serogroup. The recommended treatment for optimal clearance of the organism from renal tubules is doxycycline, 5 mg/kg PO q12h, for 14 days. Annual vaccination can prevent leptospirosis caused by serovars included in the vaccine and is recommended for dogs at risk of infection.
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影响因子：
1.6
作者：
BRYSON, DG;ELLIS, WA
通讯作者：
ELLIS, WA
影响因子：
1.6
作者：
Agunloye, CA;Nash, AS
通讯作者：
Nash, AS
影响因子：
14.2
作者：
Croda, J.;Neto, A. N. D.;Duarte, M. I. S.
通讯作者：
Duarte, M. I. S.
影响因子：
9.4
作者：
Chappel, RJ;Goris, M;Hartskeerl, RA
通讯作者：
Hartskeerl, RA
影响因子：
3.4
作者：
Cerqueira, Thaís Bandeira;Athanazio, Daniel Abensur;Seguro, Antônio Carlos
通讯作者：
Seguro, Antônio Carlos