On the use of historical control data for trend test in carcinogenicity studies.
On the use of historical control data for trend test in carcinogenicity studies.
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关于在致癌性研究中使用历史对照数据进行趋势检验。
DOI：
10.1111/j.0006-341x.1999.01273.x
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Sun,J
中科院分区：
文献类型：
--
作者：
Sun,J
历史对照数据通常在致癌性研究中可用，并在当前研究中用于测试剂量效应。提出了一种将历史对照信息纳入剂量效应试验的新方法。该方法推广了Tarone(1982，Biometrics38,215-220)和Ibrahim和Ryan(1996，Biometrics52,1478-1485)提出的检验方法，考虑了基于历史数据的参数估计引起的变化。文中给出了两个算例来说明所提出的方法。
Historical control data are often available in carcinogenicity studies and are included for testing dose effects in current studies. A new method is developed for incorporating the historical control information into a dose effect test. The method generalizes the test procedures proposed by Tarone (1982,Biometrics38, 215–220) and Ibrahim and Ryan (1996,Biometrics52, 1478–1485) by taking into account the variation resulting from parameter estimation based on historical data. Two examples are discussed for illustrating the proposed method.