Pancreatic stone protein/regenerating protein (PSP/reg): a novel secreted protein up-regulated in type 2 diabetes mellitus
Pancreatic stone protein/regenerating protein (PSP/reg): a novel secreted protein up-regulated in type 2 diabetes mellitus
复制标题
胰结石蛋白/再生蛋白（PSP/reg）：一种在 2 型糖尿病中上调的新型分泌蛋白
DOI：
10.1007/s12020-014-0427-3
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发表时间：
2015-04-01
期刊：
影响因子：
3.7
通讯作者：
Sun, Zilin
中科院分区：
文献类型：
--
作者：
Yang, Jiayue;Li, Ling;Sun, Zilin
2型糖尿病（T2 DM）具有胰岛素抵抗（IR）或β细胞质量减少，部分原因是β细胞凋亡率增加。胰腺结石蛋白/再生蛋白（PSP/reg）是胰腺中产生的分泌蛋白，在胰腺疾病期间显著上调。最近的研究表明，经历凋亡的β细胞诱导存活的邻近细胞中的PSP/reg表达。进一步的实验表明，PSP/reg在1型糖尿病（T1 DM）的疾病进展过程中升高。然而，PSP/reg和T2 DM患者之间的关联尚不清楚。本研究的目的是探讨PSP/reg在不同临床阶段的T2 DM，并评估其与糖尿病慢性并发症的相关性。共有1，121名参与者（479名男性，642名女性;年龄范围23-80岁）入组本研究。PSP/reg血清值通过新开发的酶联免疫吸附试验（ELISA）测定。分析其与T2 DM患者不同临床分期的临床及生化指标的相关性。采用SPSS17.0软件进行统计学分析。采用斯皮尔曼等级相关系数进行PSP/reg和临床参数的相关性分析。通过Nemenyi检验确定组间差异。PSP/reg在高危组和糖调节受损组（IGR）中升高（p < 0.05）。PSP/reg在新诊断的T2 DM患者和有并发症的长期糖尿病患者中显著上调（p < 0.001）。PSP/reg水平与糖尿病病程相关（p < 0.001）。糖尿病发病及其慢性并发症的曲线下面积（AUC）分别为0.640和0.754。PSP/reg在T2 DM患者中显著上调，并且PSP/reg水平与糖尿病病程相关。因此，PSP/reg可作为T2 DM和疾病进展的预测因子。
Type 2 diabetes mellitus (T2DM) has insulin resistance (IR) or reduced beta-cell mass, partially due to an increased beta-cell apoptosis rate. Pancreatic stone protein/regenerating protein (PSP/reg) is a secretory protein produced in the pancreas and up-regulated dramatically during pancreatic disease. Recent studies revealed that beta-cells undergoing apoptosis induce PSP/reg expression in surviving neighboring cells. Further experiments demonstrated that PSP/reg was elevated during disease progression in type 1 diabetes mellitus (T1DM). However, the association between PSP/reg and T2DM patients is unknown. The aim of this pilot study was to investigate PSP/reg in different clinical stages of T2DM and evaluate its correlation with chronic complications of diabetes. A total of 1,121 participants (479 males, 642 females; age range 23-80 years) were enrolled in this study. PSP/reg serum values were measured by a newly developed enzyme-linked immunosorbent assay (ELISA). We analyzed its correlation with clinical and biochemical parameters in subjects with T2DM at different clinical phases. Statistical analyses were conducted using SPSS 17.0 software. Correlations of PSP/reg and clinical parameters were performed using Spearman's rank correlation coefficient. Differences between groups were determined by Nemenyi test. PSP/reg was elevated in high-risk and impaired glucose regulation (IGR) patients (p < 0.05). PSP/reg was significantly up-regulated in newly diagnosed T2DM patients and long-term diabetes patients with complications (p < 0.001). PSP/reg levels correlated with the duration of diabetes (p < 0.001). The area under the curve (AUC) for presence of diabetes-onset and its chronic complications was 0.640 and 0.754, respectively. PSP/reg is significantly up-regulated in T2DM patients, and PSP/reg levels are related to the duration of diabetes. Therefore, PSP/reg might be useful as a predictor of T2DM and disease progression.