The association of serum anti-ribosomal P antibody with clinical and serological disorders in systemic lupus erythematosus: a systematic review and meta-analysis
The association of serum anti-ribosomal P antibody with clinical and serological disorders in systemic lupus erythematosus: a systematic review and meta-analysis
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DOI：
10.1177/0961203314560003
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发表时间：
2015-05-01
期刊：
影响因子：
2.6
通讯作者：
Wang, L.
中科院分区：
文献类型：
--
作者：
Shi, Z-R;Cao, C-X;Wang, L.
目的抗核糖体P(anti-P)抗体是系统性红斑狼疮(SLE)的血清学特异性标志。方法检索PubMed、EMBASE、Web of Science和CNKI数据库，检索相关文献。这些研究的质量是使用纽卡斯尔-渥太华量表的修改版本进行评估的。采用Mantel-Haenszel方法进行Meta分析，通过合并优势比(OR)和可信区间(CI)确定抗P抗体与临床和血清学疾病的相关性。结果共纳入16项队列研究，2355例患者。腮腺炎、口腔溃疡和光敏与血清抗P抗体密切相关，OR(95%CI)分别为2.05(1.42~2.92)、1.49(1.05~2.13)和1.44(1.08~1.91)。关节炎和肾脏受累与抗P抗体无关，而由于种族和出版偏见，观察到高度的异质性。抗P阳性患者的神经精神性SLE(NPSLE)、肝损害、抗dsDNA、抗Sm和抗心磷脂抗体(ACL)的发生率明显高于抗P阴性患者。有关肝脏受累的研究显示，精确度较低，CI(2.56-11.2)相当宽泛。结论抗P抗体与颧部皮疹、口腔溃疡、光敏反应和血清抗dsDNA抗体密切相关，并可能与NPSLE、肝损害、血清抗Sm和ACL相关。
Objective Anti-ribosomal P (anti-P) antibody is a serological specific marker of systemic lupus erythematosus (SLE). The aim of this study is to investigate the association of this antibody with clinical and serological disorders in SLE.Methods All relevant literature was retrieved from PubMed, EMBASE, Web of Science and CNKI databases. The qualities of these studies were evaluated using a modified version of the Newcastle-Ottawa scale. The associations of anti-P antibody with clinical and serological disorders were determined by the pooled odds ratio (OR) and the confidence interval (CI) calculated using meta-analysis with the Mantel-Haenszel method.Results Sixteen cohort studies with 2355 patients were included in this study. Malar rash, oral ulcer and photosensitivity were strongly associated with serum anti-P antibody, with OR (95% CI) values of 2.05 (1.42-2.92), 1.49 (1.05-2.13) and 1.44 (1.08-1.91), respectively. Arthritis and renal involvement were not associated with anti-P antibody, whereas a high heterogeneity was observed due to ethnicity and publication bias, respectively. Neuropsychiatric SLE (NPSLE), hepatic involvement, anti-dsDNA, anti-Sm and anti-cardiolipinantibodies (aCL) were observed more frequently in anti-P positive patients than in negative patients. Studies on hepatic involvement showed a low precision with substantially broad CI (2.56-11.2). A high heterogeneity presented among studies on NPSLE, anti-Sm and aCL.Conclusions Anti-P antibody is significantly associated with malar rash, oral ulcer, photosensitivity and serum anti-dsDNA antibody, and potentially associated with NPSLE, hepatic damage, serum anti-Sm and aCL.