Effects of diet soda on gut hormones in youths with diabetes.
Effects of diet soda on gut hormones in youths with diabetes.
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DOI：
10.2337/dc11-2424
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发表时间：
2012-05
期刊：
影响因子：
16.2
通讯作者：
Rother KI
中科院分区：
文献类型：
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作者：
Brown RJ;Walter M;Rother KI
在2型糖尿病患者中，但不是1型糖尿病患者中，已经描述了对口服营养物质做出反应的胰岛素的异常分泌。在健康的年轻人中，我们最近报道了在饮食苏打水中加入三氯蔗糖和安赛蜜-K后，GLP-1分泌增加。在这项研究中，我们研究了无糖汽水对青少年糖尿病患者胃肠激素的影响。年龄在12-25岁的1型糖尿病患者(n=9)或2型糖尿病患者(n=10)，或健康对照组参与者(n=25)，采用随机交叉设计，饮用240毫升可乐味无咖啡因无糖苏打水或碳酸水，然后是75克葡萄糖负荷。测定血糖、C-肽、GLP-1、葡萄糖依赖的胰岛素样生长因子(GIP)和酪氨酸(PYY)。此前已有报道称，健康对照组受试者中存在葡萄糖和GLP-1。在1型糖尿病患者中，摄入无糖汽水后的GLP-1曲线下面积(AUC)比碳酸水高43%(P=0.020)，与对照组(34%，P=0.029)相似，但在2型糖尿病患者中不受无糖汽水的影响(P=0.92)。在任何一组中，血糖、C-肽、GIP和PYY AUC在两种情况下均无统计学差异。在糖负荷之前摄入无糖汽水可增加1型糖尿病患者和对照组的GLP-1分泌，但不能增加2型糖尿病患者的GLP-1分泌。无糖苏打水不影响GIP和PYY的分泌。这种GLP-1分泌增加的临床意义，以及年轻人2型糖尿病患者中没有GLP-1分泌，需要确定。
In patients with type 2 diabetes, but not type 1 diabetes, abnormal secretion of incretins in response to oral nutrients has been described. In healthy youths, we recently reported accentuated glucagon-like peptide 1 (GLP-1) secretion in response to a diet soda sweetened with sucralose and acesulfame-K. In this study, we examined the effect of diet soda on gut hormones in youths with diabetes. Subjects aged 12–25 years with type 1 diabetes (n = 9) or type 2 diabetes (n = 10), or healthy control participants (n = 25) drank 240 mL cola-flavored caffeine-free diet soda or carbonated water, followed by a 75-g glucose load, in a randomized, cross-over design. Glucose, C-peptide, GLP-1, glucose-dependent insulinotropic peptide (GIP), and peptide Tyr-Tyr (PYY) were measured for 180 min. Glucose and GLP-1 have previously been reported for the healthy control subjects. GLP-1 area under the curve (AUC) was 43% higher after ingestion of diet soda versus carbonated water in individuals with type 1 diabetes (P = 0.020), similar to control subjects (34% higher, P = 0.029), but was unaffected by diet soda in patients with type 2 diabetes (P = 0.92). Glucose, C-peptide, GIP, and PYY AUC were not statistically different between the two conditions in any group. Ingestion of diet soda before a glucose load augmented GLP-1 secretion in type 1 diabetic and control subjects but not type 2 diabetic subjects. GIP and PYY secretion were not affected by diet soda. The clinical significance of this increased GLP-1 secretion, and its absence in youths with type 2 diabetes, needs to be determined.