Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies.
Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies.
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DOI：
10.1038/sj.bjc.6605658
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发表时间：
2010-04-27
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
评估维生素D状态与胰腺癌风险的研究得出了不一致的结果。从1986年到2006年，我们前瞻性地跟踪了护士健康研究和卫生专业人员随访研究的118，597名参与者。我们从已知的维生素D状态预测因子中计算了每个个体的25-羟基维生素D（25（OH）D）评分，然后检查了预测的25（OH）D水平与胰腺癌风险的关系。使用校正年龄、性别、种族、身高、吸烟和糖尿病的考克斯比例风险模型估计相对风险（RR）和95%置信区间（95% CI）。然后，我们在敏感性分析中进一步调整了体重指数（BMI）和身体活动。在20年的随访中，我们确定了575例胰腺癌病例。较高的25（OH）D评分与胰腺癌风险显著降低相关;与最低的五分位数相比，25（OH）D评分最高的五分位数参与者的校正RR为0.65（95% CI=0.50-0.86; Ptrend=0.001）。当我们进一步调整BMI和体力活动时，结果相似。在这两项前瞻性队列研究中，较高的25（OH）D评分与较低的胰腺癌风险相关。
Studies evaluating vitamin D status in relation to pancreatic cancer risk have yielded inconsistent results. We prospectively followed 118 597 participants in the Nurses' Health Study and Health Professionals Follow-up Study from 1986 to 2006. We calculated a 25-hydroxyvitamin D (25(OH)D) score from known predictors of vitamin D status for each individual and then examined the predicted 25(OH)D levels in relation to pancreatic cancer risk. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models adjusted for age, sex, race, height, smoking, and diabetes. We then further adjusted for body mass index (BMI) and physical activity in a sensitivity analysis. During 20 years of follow-up, we identified 575 incident pancreatic cancer cases. Higher 25(OH)D score was associated with a significant reduction in pancreatic cancer risk; compared with the lowest quintile, participants in the highest quintile of 25(OH)D score had an adjusted RR of 0.65 (95% CI=0.50–0.86; Ptrend=0.001). Results were similar when we further adjusted for BMI and physical activity. Higher 25(OH)D score was associated with a lower risk of pancreatic cancer in these two prospective cohort studies.
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影响因子：
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