Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T
Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T
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DOI：
10.1016/j.neuroimage.2008.04.174
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发表时间：
2008-08-01
期刊：
影响因子：
5.7
通讯作者：
Weiner, M. W.
中科院分区：
文献类型：
--
作者：
Mueller, S. G.;Schuff, N.;Weiner, M. W.
背景资料。在4T下可以看到海马区内部结构的细节，从而可以进行体内亚区的体积测量。本研究的目的是：1.确定载脂蛋白e4在对照组中是否具有子场特异性效应。2.研究载脂蛋白e4对阿尔茨海默病大鼠海马亚区的影响。方法：81例受试者(对照组66例，平均年龄60.8±13.6岁，年龄28~85岁)和15例AD患者(平均年龄67.5±9.3岁)。用手工标记方法测定内嗅皮层、下丘脑、CA1、CA1-CA2过渡区、CA3-4和齿状回(CA3&DG)以及海马区总体积。结果：Apoe4对总对照组人群(p=0.042)和老年对照组(6185岁)(p=0.036)的CA3和DG均有显著影响，但对年轻对照组(28-60岁)无显著影响。在老年受试者和AD受试者的子组中也发现载脂蛋白e4(p=0.0035)对CA3和DG的显著影响。有载脂蛋白e4的AD的CA3和DG小于无载脂蛋白e4的AD(p=0.027)。结论：Apoe4在正常衰老和AD患者中对CA3和DG具有区域选择性作用。(C)2008 Elsevier Inc.保留所有权利。
Background. Details of the internal hippocampal structure visible at 4 T allow for in vivo volumetry of sublields. The aims of this study were: 1. To determine if Apo e4 has subfield specific effects in controls. 2. To study the influence of Apo e4 on hippocampal sublields in AD. Methods: 81 subjects (66 controls, mean age60.8 +/- 13.6, range: 28-85 years), and 15 AD (mean age 67.5 +/- 9.3) were studied. Entorhinal cortex, subiculum, CA1, CA1-CA2 transition zone, CA3-4 and dentate gyrus (CA3&DG) and total hippocampal volume were determined using a manual marking strategy. Results: Significant effects for Apo e4 on the CA3&DG were found in the total control population (p=0.042) and in older controls (6185 years) (p=0.036) but not in younger (28-60 years) controls. Significant effects for Apo e4 (p=0.0035) on CA3&DG were also found in a subgroup of older subjects and AD subjects. AD with Apo e4 had smaller CA3&DG than AD without Apo e4 (p=0.027). Conclusions: These findings suggest that Apo e4 exerts a regionally selective effect on CA3&DG in normal aging and AD. (C) 2008 Elsevier Inc. All rights reserved.