Association between circulating adiponectin and interleukin-10 levels in android obesity:: Effects of weight loss
Association between circulating adiponectin and interleukin-10 levels in android obesity:: Effects of weight loss
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DOI：
10.1210/jc.2005-0281
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发表时间：
2005-10-01
影响因子：
5.8
通讯作者：
Davì, G
中科院分区：
文献类型：
--
作者：
Manigrasso, MR;Ferroni, P;Davì, G
目的：脂联素抑制人巨噬细胞血管炎症并增加IL-10 mRNA的表达。因此，我们研究了血浆脂联素和IL-10水平之间的可能关系，以及饮食诱导的适度体重减轻对这两种细胞因子的影响。患者和研究设计：分析64例体重指数（BMI）为28 kg/m(2)的受试者血浆脂联素和IL-10水平；腰臀比（WHR）， >= 0.86]和20 gynoid [BMI， > 28 kg/m(2)]；WHR < 0.86]。Android肥胖女性（49 +/- 14岁）的平均BMI为37.1 +/- 5.3 kg/m(2)，与雌性肥胖女性（49 +/- 11岁；BMI为33.4 +/- 2.6 kg/m(2)）相似。还研究了20名非肥胖对照妇女（46 +/- 11岁；BMI 25.2 +/- 2.2 kg/m(2)）。在15名机器人肥胖女性中，在12周的节食期（1200千卡/天）后重复测量。结果：中位脂联素[5.2（范围，3.3 - 7.8）vs. 12.1 (9.7 - 13.9) vs. 15.0 (12.6 - 18.2) mu g/ml；P < 0.0001)和il - 10[1.8(1.2 - 3.3)和3.5(2.9 - 4.3),和4.1 (3.5 - 4.8)pg / ml;P < 0.0001]，安卓型、雌体型和非肥胖女性的水平较低。在肥胖女性中，低脂联素水平与IL-10水平降低独立相关（P < 0.0001），与BMI、WHR或胰岛素抵抗无关。体重减轻后，脂联素和IL-10的中位水平均无显著变化（8 +/- 4 kg; P < 0.01），但脂联素的百分比变化与IL-10的百分比变化相似（P < 0.05）。结论：Android肥胖与IL-10和脂联素水平的降低相关。然而，肥胖的抗炎状态可能需要长时间的能量限制饮食才能恢复正常。
Objective: Adiponectin inhibits vascular inflammation and increases IL-10 mRNA expression in human macrophages. Thus, we investigated the possible relationship between plasma adiponectin and IL-10 levels and the effects of a diet-induced moderate weight loss on both cytokines.Patients and Study Design: Plasma adiponectin and IL-10 levels were analyzed in 64 android [body mass index ( BMI), > 28 kg/m(2); waist to hip ratio (WHR), >= 0.86] and 20 gynoid [BMI, > 28 kg/m(2); WHR, < 0.86] obese healthy women. Android obese women (49 +/- 14 yr) had a mean BMI of 37.1 +/- 5.3 kg/m(2), similar to that of gynoid obese women (49 +/- 11 yr; BMI, 33.4 +/- 2.6 kg/m(2)). Twenty nonobese control women (46 +/- 11 yr; BMI, 25.2 +/- 2.2 kg/m(2)) were also studied. In 15 android obese women, measurements were repeated after a 12-wk diet period (1200 kcal/d).Results: Median adiponectin [5.2 (range, 3.3 - 7.8) vs. 12.1 (9.7 - 13.9) vs. 15.0 (12.6 - 18.2) mu g/ml; P < 0.0001] and IL-10 [1.8 (1.2 - 3.3) vs. 3.5 (2.9 - 4.3) and vs. 4.1 (3.5 - 4.8) pg/ml; P < 0.0001] levels were lower in android vs. gynoid vs. nonobese women. Among android obese women, low adiponectin levels were independently related (P < 0.0001) to decreased IL-10 levels, independently of BMI, WHR, or insulin resistance. No significant change in either median adiponectin or IL-10 levels was observed after body weight reduction (8 +/- 4 kg; P < 0.01), although percent changes in adiponectin paralleled those in IL-10 (P < 0.05).Conclusions: Android obesity is associated with a concomitant reduction of IL-10 and adiponectin levels. However, the antiinflammatory status of obesity might require prolonged periods of energy-restricted diets to revert to normal.