DEVELOPMENT OF MOUSE DORSAL ROOT-GANGLIA - AUTORADIOGRAPHIC AND QUANTITATIVE STUDY
DEVELOPMENT OF MOUSE DORSAL ROOT-GANGLIA - AUTORADIOGRAPHIC AND QUANTITATIVE STUDY
复制标题
DOI：
10.1007/bf01236122
复制
发表时间：
1979-01-01
期刊：
影响因子：
--
通讯作者：
BISCOE, TJ
中科院分区：
文献类型：
--
作者：
LAWSON, SN;BISCOE, TJ
用[3H]胸腺嘧啶核苷脉冲标记法测定胎鼠背根神经节（DRG）神经元的细胞生日。在颈DRG中，细胞出生的峰值数出现在胎龄11.5天，而在腰DRG中，细胞出生的峰值数出现在胎龄12.5天。到第13.5天，腰椎和颈部区域的卫星细胞被大量标记。在13天时，在腰椎区域观察到非常尖锐的卫星细胞标记峰。存在> 1种神经元细胞类型的证据。最早停止分裂的细胞是广泛分布的一部分，其中包括所有大型神经元。小神经元群体的生日开始较晚，并在大细胞分裂停止后持续至少48小时。
Pulse labeling with [3H]thymidine was used to determine the cell birthdays of dorsal root ganglion (DRG) neurons in fetal mice. The peak number of cell birthdays occurred at 11.5 days fetal age in cervical DRG, and at 12.5 days in lumbar DRG. The satellite cells were becoming heavily labeled by day 13.5 in lumbar and some hours earlier in cervical regions. A very sharp peak of satellite cell labeling was seen at 13 days in the lumbar region. Evidence for the existence of > 1 neuronal cell type is presented. The earliest cells to stop dividing were part of a widely spread distribution which included all the large neurons. The birthdays of the population of small neurons began later and continued for at least 48 h after division of the large cells had ceased.