MRI lesion volume measurement in multiple sclerosis and its correlation with disability: a comparison of fast fluid attenuated inversion recovery (fFLAIR) and spin echo sequences
MRI lesion volume measurement in multiple sclerosis and its correlation with disability: a comparison of fast fluid attenuated inversion recovery (fFLAIR) and spin echo sequences
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DOI：
10.1136/jnnp.64.2.197
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发表时间：
1998-02-01
影响因子：
11
通讯作者：
Miller, DH
中科院分区：
文献类型：
--
作者：
Gawne-Cain, ML;O'Riordan, JI;Miller, DH
Objectives-To assess whether multiple sclerosis lesion volume measurements derived using the fast fluid attenuated inversion recovery（fFLAIR）sequence show better reproducibility or correlation with disability than those derived using the conventional spin echo（CSE）sequence.Methods-Part I：25 patients with multiple sclerosis were scanned with CSE，fast spin echo（FSE），and fFLAIR.使用局部阈值分割技术对每个序列确定两次病变体积。第二部分：对56例多发性硬化患者进行CSE和fFLAIR扫描。Kurtzke扩展残疾量表（EDSS）和功能系统评分（FSS）进行了比较，总的和区域脑病变体积。结果第一部分：分析时间显着长于CSE比FSE或fFLAIR。三种序列的重复性无显著差异。第二部分：总病变体积相似，但CSE的后颅窝病变体积显著更大，fFLAIR的皮质下病变体积显著更大。两种序列的总体积与EDSS之间存在显著相关性（CSE r=0.49; fFLAIR r=0.44）。两个序列的相关性表现出微小的差异时，解剖区域和FSS被认为是independent. Conclusions CSE，FSE，和fFLAIR是同样可重复的; FSE产量低于CSE的体积; fFLAIR提供类似的体积CSE，但强调后颅窝。CSE和fFLAIR的总体临床相关性相似。
Objectives-To assess whether multiple sclerosis lesion volume measurements derived using the fast fluid attenuated inversion recovery (fFLAIR) sequence show better reproducibility or correlation with disability than those derived using the conventional spin echo (CSE) sequence.Methods-Part I: twenty five patients with multiple sclerosis were scanned with CSE, fast spin echo (FSE), and fFLAIR. Lesion volume was determined twice for each sequence using a local threshold segmentation technique. Part II: fifty six patients with multiple sclerosis were scanned with CSE and fFLAIR. Total and regional brain lesion volumes were compared with the Kurtzke extended disability scale (EDSS) and functional systems scores (FSS).Results-Part I: analysis times were significantly longer for CSE than for FSE or fFLAIR. There was no significant difference in the reproducibility of the three sequences. Part II: total lesion volumes were similar but posterior fossa lesion volumes were significantly greater for CSE and subcortical lesion volumes significantly greater for fFLAIR. There was a significant correlation between total volume and EDSS with both sequences (CSE r=0.49; fFLAIR r=0.44). Correlations for the two sequences showed minor differences when anatomical region and FSS were considered separately.Conclusions-CSE, FSE, and fFLAIR are equally reproducible; FSE yields lower volumes than CSE; fFLAIR gives similar volumes to CSE but underscores the posterior fossa. Overall clinical correlations are similar for CSE and fFLAIR.