Enhanced pedigree error detection
Enhanced pedigree error detection
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DOI：
10.1159/000067666
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发表时间：
2002-01-01
期刊：
影响因子：
1.8
通讯作者：
McPeek, MS
中科院分区：
文献类型：
--
作者：
Sun, L;Wilder, K;McPeek, MS
研究中个体间关系的准确信息对于有效的连锁分析至关重要。我们扩展了MLLR，EIBD，AIBS和IBS测试检测错误指定的关系，以更广泛的相对对，我们改进了两阶段的筛选程序，用于分析大型数据集。我们已经开发了软件，PREST，它计算的检验统计量，并进行相应的假设检验的关系误分类一般远交家系。当检测到潜在的系谱错误时，我们的配套程序ALTERTEST可用于确定哪些关系与基因型数据相容。这两个程序现在都可以在网上免费获得。版权所有（C）2003 S，Karger AG，巴塞尔。
Accurate information on the relationships among individuals in a study is critical for valid linkage analysis. We extend the MLLR, EIBD, AIBS and IBS tests for detection of misspecified relationships to a broader range of relative pairs, and we improve the two-stage screening procedure for analyzing large data sets. We have developed software, PREST, which calculates the test statistics and performs the corresponding hypothesis tests for relationship misclassification in general outbred pedigrees. When a potential pedigree error is detected, our companion program, ALTERTEST, can be used to determine which relationships are compatible with the genotype data. Both programs are now freely available on the web. Copyright (C) 2003 S, Karger AG, Basel.