Evaluation of Glaucoma Progression in Large-Scale Clinical Data: The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG)
Evaluation of Glaucoma Progression in Large-Scale Clinical Data: The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG)
复制标题
DOI：
10.1167/iovs.15-19046
复制
发表时间：
2016-04-01
影响因子：
4.4
通讯作者：
Shoji, Nobuyuki
中科院分区：
文献类型：
--
作者：
Fujino, Yuri;Asaoka, Ryo;Shoji, Nobuyuki
目的.建立一个大规模的青光眼真实的临床数据库（日本青光眼多中心数据库：JAMDIG），并研究治疗效果。本研究共纳入805例原发性开角型青光眼患者的1348只眼，使用24-2或30-2 Humphrey视野分析仪（HFA）测量10个视野（VF）和日本10个研究所的眼内压（IOP）记录。进一步确定了具有10个可靠VF的患者（417例患者的638只眼）。计算24-2 HFA VF中52个测试点的平均总偏差（mTD），并分析mTD进展率与7个变量（年龄、基线VF的mTD、平均IOP、IOP标准差（SD）、既往氩离子/选择性激光小梁成形术（ALT/ALT）、既往小梁切除术和既往小梁切开术）之间的关系。初始VF的mTD为-6.9 +/- 6.2 dB，mTD进展率为-0.26 +/- 0.46 dB/年。随访期间的平均IOP为13.5 ± 2.2 mm Hg。年龄和眼压SD与mTD进展率相关。然而，在平均IOP低于15和13 mm Hg的眼中，只有年龄和基线VF mTD与mTD进展率相关。年龄和VF损伤程度与未来进展有关。平均IOP与进展率无关;然而，IOP波动与更快的进展相关，尽管当平均IOP低于15 mm Hg时并非如此。
PURPOSE. To develop a large-scale real clinical database of glaucoma (Japanese Archive of Multicentral Databases in Glaucoma: JAMDIG) and to investigate the effect of treatment.METHODS. The study included a total of 1348 eyes of 805 primary open-angle glaucoma patients with 10 visual fields (VFs) measured with 24-2 or 30-2 Humphrey Field Analyzer (HFA) and intraocular pressure (IOP) records in 10 institutes in Japan. Those with 10 reliable VFs were further identified (638 eyes of 417 patients). Mean total deviation (mTD) of the 52 test points in the 24-2 HFA VF was calculated, and the relationship between mTD progression rate and seven variables (age, mTD of baseline VF, average IOP, standard deviation (SD) of IOP, previous argon/selective laser trabeculoplasties (ALT/SLT), previous trabeculectomy, and previous trabeculotomy) was analyzed.RESULTS. The mTD in the initial VF was -6.9 +/- 6.2 dB and the mTD progression rate was -0.26 +/- 0.46 dB/year. Mean IOP during the follow-up period was 13.5 +/- 2.2 mm Hg. Age and SD of IOP were related to mTD progression rate. However, in eyes with average IOP below 15 and also 13 mm Hg, only age and baseline VF mTD were related to mTD progression rate.CONCLUSIONS. Age and the degree of VF damage were related to future progression. Average IOP was not related to the progression rate; however, fluctuation of IOP was associated with faster progression, although this was not the case when average IOP was below 15 mm Hg.