Simultaneous synthesis of types I and III collagen by fibroblasts in culture.
Simultaneous synthesis of types I and III collagen by fibroblasts in culture.
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培养中的成纤维细胞同时合成 I 型和 III 型胶原蛋白。
DOI：
10.1073/pnas.73.11.4037
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发表时间：
1976
影响因子：
11.1
通讯作者：
Klaus Kuhn
中科院分区：
文献类型：
--
作者：
Steffen Gay;George R. MARTINt;Peter K. Muller;R. Timpl;Klaus Kuhn
针对I型和III型胶原和前胶原的特异性抗体用于在培养的人细胞中定位这些蛋白。这些研究表明，同一细胞产生这两种蛋白质。2例Ehlers-Danlos IV型综合征患者的细胞中未观察到III型前胶原合成。
Specific antibodies against types I and III collagens and procollagens were used to localize these proteins in cultured human cells. These studies indicate that the same cell makes both proteins. No type III procollagen synthesis was observed in cells from two patients with two patients with the Ehlers-Danlos type IV syndrome.