Ocular Blood Flow Autoregulation Mechanisms and Methods.
Ocular Blood Flow Autoregulation Mechanisms and Methods.
复制标题
眼血流自动调节机制和方法
DOI：
10.1155/2015/864871
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发表时间：
2015
影响因子：
1.9
通讯作者：
Shen Y
中科院分区：
文献类型：
--
作者：
Luo X;Shen YM;Jiang MN;Lou XF;Shen Y
眼部血流的主要功能是为眼睛提供足够的氧气和营养。局部血管阻力调节眼睛的整体血液分布，并且可以根据眼睛的需要随着时间的推移而迅速变化。在正常情况下，眼睛的血流量和灌注压之间的关系是自动调节的。基本上，自动调节是在眼灌注压变化和代谢需求变化的情况下维持相对恒定的血流水平的能力。此外，眼部血流失调已被证明是许多眼部疾病的独立危险因素。例如，眼灌注压在青光眼和糖尿病视网膜病变等视网膜病变的进展中起着关键作用。在这篇综述中，讨论了测量眼血流量的不同直接和间接技术以及肌源性和神经源性机制对眼血流的影响。此外，将描述眼部疾病中的眼部血流调节。
The main function of ocular blood flow is to supply sufficient oxygen and nutrients to the eye. Local blood vessels resistance regulates overall blood distribution to the eye and can vary rapidly over time depending on ocular need. Under normal conditions, the relation between blood flow and perfusion pressure in the eye is autoregulated. Basically, autoregulation is a capacity to maintain a relatively constant level of blood flow in the presence of changes in ocular perfusion pressure and varied metabolic demand. In addition, ocular blood flow dysregulation has been demonstrated as an independent risk factor to many ocular diseases. For instance, ocular perfusion pressure plays key role in the progression of retinopathy such as glaucoma and diabetic retinopathy. In this review, different direct and indirect techniques to measure ocular blood flow and the effect of myogenic and neurogenic mechanisms on ocular blood flow are discussed. Moreover, ocular blood flow regulation in ocular disease will be described.