Translational Selection Frequently Overcomes Genetic Drift in Shaping Synonymous Codon Usage Patterns in Vertebrates
Translational Selection Frequently Overcomes Genetic Drift in Shaping Synonymous Codon Usage Patterns in Vertebrates
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DOI：
10.1093/molbev/mst128
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发表时间：
2013-10-01
影响因子：
10.7
通讯作者：
McInerney, James O.
中科院分区：
文献类型：
--
作者：
Doherty, Aoife;McInerney, James O.
同义密码子的使用模式是由突变、漂移和自然选择之间的平衡形成的。到目前为止，脊椎动物翻译选择的检测已经被证明是一项具有挑战性的任务，被较大动物的小的长期有效种群规模和一些物种中等轴线的存在所掩盖。人们的共识是，在这类物种中，自然选择要么在克服突变压力和基因漂移方面完全无效，要么可能是有效的，但太弱了，以至于无法检测到。这项研究的目的是了解脊椎动物的突变、选择和遗传漂移之间的相互作用。我们观察到，尽管突变偏向的变化无疑是影响密码子使用的主导力量，但翻译选择对同义密码子的使用起到了微弱的辅助作用。这些观察表明，翻译选择在脊椎动物中是一种普遍的现象，并不局限于少数物种。
Synonymous codon usage patterns are shaped by a balance between mutation, drift, and natural selection. To date, detection of translational selection in vertebrates has proven to be a challenging task, obscured by small long-term effective population sizes in larger animals and the existence of isochores in some species. The consensus is that, in such species, natural selection is either completely ineffective at overcoming mutational pressures and genetic drift or perhaps is effective but so weak that it is not detectable. The aim of this research is to understand the interplay between mutation, selection, and genetic drift in vertebrates. We observe that although variation in mutational bias is undoubtedly the dominant force influencing codon usage, translational selection acts as a weak additional factor influencing synonymous codon usage. These observations indicate that translational selection is a widespread phenomenon in vertebrates and is not limited to a few species.