RNA m6A modification in liver biology and its implication in hepatic diseases and carcinogenesis.
RNA m6A modification in liver biology and its implication in hepatic diseases and carcinogenesis.
复制标题
肝脏生物学中的 RNA m6A 修饰及其在肝脏疾病和癌变中的意义。
DOI：
10.1152/ajpcell.00214.2022
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Wu,Tong
中科院分区：
文献类型：
--
作者：
Ma,Wenbo;Wu,Tong
N6-甲基腺苷(M6A)是真核RNA中最普遍的内部修饰。这种修饰受三种不同因素(写入器、擦除器和读取器)的调节，并影响RNA代谢的多个方面，包括RNA剪接、核输出、翻译、稳定性和腐烂。M6A介导的修饰在基因表达的转录后调控中起着重要作用，并介导了多种细胞和生物过程。因此，M6A修饰中的去调控与人类疾病的发生和发展密切相关。肝脏是人类最大的消化和代谢器官，最近的研究表明，M6A修饰在肝脏的细胞和生理功能以及肝脏疾病和癌症的发病机制中具有重要意义。本文综述了m6A在RNA代谢中的作用及其在肝细胞生物学中的作用，并讨论了其在肝脏疾病和肿瘤发生中的意义。
N6-methyladenosine (m6A) is the most prevalent internal modification in eukaryotic RNAs. This modification is regulated by three different factors (writers, erasers, and readers) and affects multiple aspects of RNA metabolism, including RNA splicing, nuclear export, translation, stability and decay. The m6A-mediated modification plays important roles in posttranscriptional regulation of gene expression and mediates a variety of cellular and biological processes. Accordingly, deregulation in m6A modification is closely related to the occurrence and development of human diseases. The liver is the largest digestive and metabolic organ in human and recent studies have shown that m6A modification is importantly implicated in liver cellular and physiological functions and in the pathogenesis of hepatic diseases and cancers. In the current review, we summarize the functions of m6A in RNA metabolism and its roles in liver cell biology and discuss its implication in hepatic diseases and carcinogenesis.