New era for personalized medicine: the diagnosis and management of age-related macular degeneration.
New era for personalized medicine: the diagnosis and management of age-related macular degeneration.
复制标题
DOI：
10.1111/j.1442-9071.2009.02136.x
复制
发表时间：
2009-11
影响因子：
4
通讯作者：
Guymer RH
中科院分区：
文献类型：
--
作者：
Baird PN;Hageman GS;Guymer RH
可以说，年龄相关性黄斑变性是最具特征的复杂性状疾病之一。存在与遗传和环境风险因素有关的广泛信息，并且许多不同的生物途径强烈地涉及其病因。沿着最近高通量和相对便宜的遗传技术的改进，我们现在能够考虑开发一种症状前的个性化方法来评估、管理和治疗这种疾病。我们探讨了这种方法的适用性和挑战，如果它是成为司空见惯的指导治疗决策的个人与预先存在的疾病或发展它的高风险。
It can be argued that age-related macular degeneration is one of the best characterized complex trait diseases. Extensive information related to genetic and environmental risk factors exists, and a number of different biological pathways are strongly implicated in its aetiology. Along with recent improvements in high throughput and relatively inexpensive genetic technologies, we are now in a position to consider developing a presymptomatic, personalized approach towards the assessment, management and treatment of this disease. We explore the applicability and challenges of this approach if it is to become commonplace for guiding treatment decisions for individuals with pre-existing disease or for those at high risk of developing it.